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Dr. Park Ji-Youn: Nucleofill, the future of skinimalism and anti ageing treatments?

April 4, 2022
Pretty Ladies

Touted by Vogue as a top beauty trend for 2022, skinimalism is a spartan approach that involves stripping back skincare and make-up routines in order to let one’s real skin shine. This can be done in a number of ways, such as reducing the number of skincare products you use or simply packing less foundation onto the skin.

As a result, patients are now seeking low-maintenance treatments that carry more longevity. Likewise, the aesthetic industry’s focus has also shifted from restoring the look of one’s skin to improving skin health from deep within.

Think treatments that allow your body to slow down the ageing process naturally through collagen biostimulation. 

In this article, we’ll talk about the treatments you should be looking at, especially in light of anti-ageing, skin safety, and looking your best from within – all aboard the skinimalism bus!

What is biostimulation, and how does it achieve skinimalism?

Biostimulation1 is an injective therapy that’s aimed at boosting the anabolic functions of dermal fibroblasts to obtain skin improvement. 

Sounds confusing? Don’t worry. Let’s break it down:

  • Anabolism: Our anabolic functions work to free and capture energy in our body.
  • Dermal fibroblasts: While they might sound like weapons from Star Wars, dermal fibroblasts are cells within the dermis that generate connective tissue and allow the skin to recover from injury.
  • Dermis: Skin comes in 3 layers. The dermis is the layer of skin above the subcutaneous layer and beneath epidermis.

When we speak of collagen biostimulators, they can be explained simply as non-invasive treatments that work to stimulate your own collagen production, correcting signs of ageing such as loss of elasticity. 

As such, biostimulation offers individuals a quick, safe, and effective way of achieving youthful, firmer skin. This is where Nucleofill comes in.

The Nucleofill difference

As one of the newest technologies in biostimulation, Nucleofill is a polynucleotide-based injectable gel that is specifically designed to revive dull and tired skin.

By stimulating deeper layers and dermal fibroblasts of our skin, this highly viscoelastic gel effectively improves the quality of skin by:

  • Acting as a scavenger against free radicals (unstable molecules that damage skin)
  • Promoting the metabolic activity of cells to restore and maintain youthful functionality
  • Producing new collagen in the skin for a natural tissue lift and skin volumisation

As such, clients who’ve undergone Nucleofill treatment can expect to experience these long-lasting results:

  • Increased skin elasticity
  • Intensely hydrated layers of skin
  • Revitalised skin tone and texture
  • Reinvigorated cell function and activity
  • Lifting and anti-ageing outcomes
  • Repair of skin tissue and damaged cells
  • Immense protection and recovery of the skin
  • Deep bio-remodelling and lifting effects

Additionally, Nucleofill, which was formulated in Italy, is well-known for its safety: Not only is it derived from bio-compatible salmon DNA which offers the skin a younger, healthier appearance, it is also suitable for all skin types.

At Ozhean Zoey, we utilise a safe 5-point injection technique to target our clients’ key tissues for optimal biostimulation and collagen production. 

How are fillers different from biostimulators?

While dermal fillers work to boost hyaluronic acid levels to enhance and volumise skin, biostimulators boost the collagen levels in the skin to improve its long-term tone, texture, and overall health.

For example, hyaluronic acid (HA) fillers plump skin because hyaluronic acid attracts water, which immediately hydrates the skin. But while HA has been known to boost collagen in the skin, it is not nearly as effective as biostimulators.

Here are some other ways that Nucleofill differs from other treatments available today:



HA fillers



What it is

Nucleofill is an innovative biotechnology that contains polynucleotides  which stimulate the skin.

Hyaluronic acid (HA) is a substance that’s  found in our skin. HA fillers help attract water to voluminise the skin.

As a non-HA filler, it contains Poly-Caprolactone (PCL) microspheres suspended in a gel-carrier made up of Carboxymethycellulose (CMC). 

Sculptra contains poly-L-lactic acid (PLLA), which is a biocompatible synthetic that stimulates collagen production.


- Youthful look

- Vibrant complexion

- Natural filling

- Face lifting

- Face shaping

- Improved tone, texture and elasticity

- Skin improvement is significant and notable

- HA is hydrophilic (tends to mix with, dissolve in, or be wetted by water), and while it helps to plump skin, may also cause puffiness after filling.

- Volumising and Collagen-stimulating effects

- Skin improvement is significant and notable

- Natural shaping

- Face lifting

Length of results

Results are long-term and last at least 6 months.

Treatment needs to be repeated thrice, and every 15 to 30 days to be continuous, long-lasting, and effective.

Results last anywhere between 9 to 24 months.

Results can be long-lasting, but it is difficult to predict final outcomes.

Initially, results may also decline before increasing.

Results are long-lasting, as with Nucleofill. Some prefer Sculptra over Ellanse as the results are gradual and more discreet.

Treatment cost in Singapore

Low (compared to Ellanse)

Medium (depending on volume)



Potential side effects

There are no serious side effects, making Nucleofilll an effective and safe treatment for all skin types2.

The most common adverse effects include tenderness, bruising, and swelling. These side effects typically resolve naturally within 2 weeks. 

Like HA fillers, side effects of Ellansé include bruising and tenderness3. 

While extremely rare, side effects can include granulomas, scarring and discolouration, nodules, and lumps.

Should I undergo Nucleofill biostimulator treatment?

If you’re looking to regenerate your skin tissues and skin from within, and are looking for more than a quick glow up, Nucleofill is an effective solution for correcting fine lines, wrinkles, and loss of elasticity. I especially recommend it for mature individuals who wish to regain their collagen levels and youthfulness.

Additionally, Nucleofill is an effective solution for anyone who suffers from:

  • Asphyxial skin
  • Dehydrated skin
  • Stretch marks
  • Scars and wounds
  • Loose skin and/or poor circulation
  • Skin that has been damaged by oxidative stress

If you’re already on a low maintenance anti-ageing regime, Nucleofill would be the perfect complement. 

Remember, skin health is a cornerstone of one’s beauty – you’re never too young to start on an anti-ageing routine! 

About Dr. Park Ji-Youn

Dr. Park Ji-Youn is the founder and managing director of the Ozhean group. As a board certified dermatologist, she has published more than 30 scientific papers on dermatology, and is the creator of Ozhean’s SKIN FIT program, which was conceived in 2015, and continues to successfully retain 80% of its original customers.


  1. Avantaggiato, A., Martinelli, M., Palmieri, A., Pascali, M., Bertuzzi, G., & Carinci, F. (2015). HYALURONIC ACID: THE USE OF ITS PRECURSOR IN SKIN BIO-STIMULATION. Journal of biological regulators and homeostatic agents, 29(3), 647–654.
  2. Park, K. Y., Seok, J., Rho, N. K., Kim, B. J., & Kim, M. N. (2016). Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients. Dermatologic therapy, 29(1), 37–40. https://doi.org/10.1111/dth.12299
  3. de Melo, F., Nicolau, P., Piovano, L., Lin, S. L., Baptista-Fernandes, T., King, M. I., Camporese, A., Hong, K., Khattar, M. M., & Christen, M. O. (2017). Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé®). Clinical, cosmetic and investigational dermatology, 10, 431–440. https://doi.org/10.2147/CCID.S145195
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