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Science-led skin regeneration
Skin repair, not just skin glow
Where collagen health comes first
Science-led
skin regeneration
Skin repair,
not just skin glow
Where collagen
health comes first
PN Skin Booster is an injectable skin treatment developed using polynucleotides (PN) — biologically active DNA fragments that support skin repair, collagen renewal, and long-term skin quality. First introduced into aesthetic medicine around 2014, PN-based treatments originated from regenerative medicine and gradually became established as a trusted approach for improving skin health beyond surface hydration. In Singapore, PN Skin Boosters have gained popularity as patients increasingly seek treatments that strengthen the skin from within rather than deliver short-lived cosmetic effects.
Traditionally, PN formulations were derived from salmon DNA, known for their biocompatibility and reparative properties. More recently, trout-derived polynucleotides have been introduced and are gaining attention for their stability and regenerative potential.
At Ozhean Zoey, both types of PN are used thoughtfully and strategically, based on individual skin condition, sensitivity, and treatment goals. By understanding the strengths of different PN formulations, our medical team customises treatment plans to support healthier, more resilient skin — in line with our collagen-focused, regenerative approach to aesthetic care.
PN Skin Booster works by supporting the skin’s natural repair and regeneration processes at a cellular level. Polynucleotides act as biological signaling molecules that help improve the skin environment, encouraging collagen-producing cells to function more effectively and enhancing overall skin resilience, texture, and hydration over time. Rather than filling or volumising the skin, PN Skin Booster focuses on restoring skin quality from within, making it suitable for patients seeking gradual, natural-looking improvement.
Different PN Skin Boosters are derived from different biological sources, most commonly salmon or trout DNA. While both work on the same regenerative principles, their characteristics may vary in terms of structure, purity, and behaviour within the skin.
At Ozhean Zoey, these differences are carefully considered during consultation, allowing our doctors to select and apply PN Skin Boosters in a way that matches each patient’s skin condition, sensitivity, and treatment goals — maximising effectiveness while maintaining comfort and safety.
PN Skin Booster is commonly used to improve overall skin quality and support skin repair in areas where the skin appears tired, damaged, or weakened over time. By enhancing the skin’s regenerative environment, it is suitable for patients seeking gradual, natural-looking improvement rather than instant or superficial results.
Common Skin Concerns Addressed
Dull, dehydrated, or
fatigued-looking skin
Skin weakened
by sun exposure
or environmental stress
PN Skin Booster is particularly favoured for patients whose skin has become less resilient with age, stress, or repeated procedures, and who wish to restore healthier skin function over time.
Treatment Areas
Cheeks
Neck
Décolletage
Other areas
with thinning or ageing skin
Under-Eye Region
Hands
Neck
Décolletage
Other areas
with thinning or ageing skin
Under-Eye
Region
Hands
At Ozhean Zoey, treatment areas are selected based on individual skin assessment rather than a fixed protocol. This allows PN Skin Booster to be applied strategically and safely, whether the goal is targeted repair or overall skin quality maintenance.
Different PN sources, such as salmon or trout-derived polynucleotides, share the same regenerative principle but may behave slightly differently within the skin. At Ozhean Zoey, these characteristics are carefully considered so each PN Skin Booster treatment is applied thoughtfully and purposefully, in line with the patient’s skin condition and long-term skin health goals.
Improves skin texture
and smoothness
Enhances skin hydration
and resilience
Supports collagen renewal
for healthier-looking skin
Refines the appearance
of pores
Helps skin recover from
environmental stress and ageing
Strengthens compromised
or sensitive skin
Because PN Skin Booster focuses on skin health at a cellular level, results tend to develop gradually and naturally, making it suitable for patients who prefer subtle, long-term improvement rather than dramatic or artificial changes.
At Ozhean Zoey, PN Skin Booster is often incorporated into a long-term skin maintenance or regenerative plan, especially for patients seeking to preserve skin quality, restore weakened skin, or complement other collagen-based treatments.
| Feature / Focus | PN Skin Booster | Hyaluronic Acid (HA)–based Boosters | ECM-Focused Boosters (e.g., RE20) |
|---|---|---|---|
| Primary Mechanism | Supports cellular repair & skin regeneration | Hydration and temporary volume enhancement | Targets extracellular matrix support & structural rebuilding |
| Core Action | Enhances skin’s internal environment; supports fibroblast activity | Attracts and retains water in dermis | Encourages deeper restructuring and resilience of dermal framework |
| Typical Outcomes | Improved skin texture, resilience, collagen support | Immediate hydration, plumped feel | Stronger structural support, deeper quality improvement |
| Onset of Results | Gradual, cumulative | Immediate hydration, followed by gradual | Gradual with structural emphasis |
| Longevity | Moderate to longer with repeat courses | Shorter, dependent on hydration effect | Moderate to longer with structural focus |
| Ideal For | Weakened skin, early signs of ageing, environment-stressed skin | Dryness, dull skin, surface hydration | Skin needing deeper ECM support, resilience, and quality |
At Ozhean Zoey, we recognise that skin health is more than hydration or surface glow — it depends on a balanced and resilient extracellular matrix (ECM), where collagen, elastin, and supportive proteins work together to maintain structure and function.
This synergy aligns with Ozhean Zoey’s collagen-first philosophy, providing patients with a holistic strategy that goes beyond hydration, supporting healthier, more resilient skin over time.
At our clinic, we understand that every individual's acne scars are unique. That's why each treatment plan is carefully tailored to your specific skin condition and scar type, ensuring optimal results. Our personalized approach begins with a thorough assessment of your skin, allowing us to recommend the most effective combination of procedures for your needs.
A seasoned aesthetic physician with a strong surgical foundation, he has over 15 years of medical experience spanning multiple subspecialties. Trained under the National Healthcare Group and holding postgraduate surgical qualifications, his practice is grounded in precision, anatomical accuracy, and safety. He focuses on facial harmony, structural refinement, and collagen-based regenerative treatments, with a philosophy centred on thoughtful decision-making, conservative execution, and long-term, natural ageing.
A dedicated physician with a background in family medicine, ENT, anaesthesia, dermatology, and aesthetic medicine. With experience in clinical dermatology, facial reconstruction, and collagen-based treatments, he focuses on anti-aging and long-term skin health. He believes in personalised and holistic care, combining medical expertise with artistic sensibility to support each patient’s confidence and well-being.
Dr. Tan Jun Yang is an aesthetic physician with a clinical background spanning Cardiothoracic Surgery, Anaesthesia, General Surgery, and Dermatology. His time at the National Heart Centre Singapore and the National University Hospital Heart Centre gave him extensive surgical training in complex heart and lung conditions as well as post-operative reconstructive procedures, a depth of experience that allows him to deliver results with confidence, consistency, and the utmost commitment to safety.
PN Skin Booster works by supporting the skin’s natural repair processes, so results tend to appear gradually rather than immediately. Many patients notice improvements in skin hydration and texture within a few weeks, with continued enhancement in skin quality as the skin regenerates over time.
Results vary depending on individual skin condition, lifestyle, and treatment plan. With an appropriate treatment course and maintenance, improvements in skin quality can be long-lasting, as PN Skin Booster supports ongoing skin repair rather than offering a temporary surface effect.
A typical PN Skin Booster treatment session takes approximately 20 to 30 minutes, excluding consultation and preparation time.
Treatment frequency is personalised. PN Skin Booster is commonly performed as a course of sessions, followed by maintenance treatments depending on skin needs and goals. Your doctor will advise on a suitable schedule after assessment.
Discomfort is generally mild and well tolerated. Measures may be taken to improve comfort during the procedure, and most patients find the treatment manageable.
PN Skin Booster is generally well tolerated when administered by trained medical professionals. Temporary effects such as mild redness, swelling, or small injection marks may occur and usually resolve within a short period.
Downtime is typically minimal. Most patients are able to resume normal daily activities shortly after treatment, although individual responses may vary.
Yes. PN Skin Booster is often combined with other aesthetic or collagen-focused treatments as part of a holistic skin health plan. Your doctor will advise on suitable combinations and timing based on your skin condition.
The cost of PN Skin Booster treatment varies depending on the treatment plan, number of sessions required, and individual skin needs. A personalised recommendation and pricing will be discussed during consultation.
111 Somerset Road #04-12/13/14 TripleOne Somerset Singapore 238164
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Tue - 10:30 am - 6:30 pm
Sat - 9:30 am - 6:30 pm
Sundays & Public Holidays - Closed
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