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Nucleofill Singapore


As the newest concept in biostimulation, Nucleofill is a polynucleotide-based injectable gel that is specifically designed to revive dull and tired skin. This highly viscoelastic gel effectively revitalises skin tone, heals wounds, and repairs skin tissue by penetrating and stimulating deeper layers of the skin. In addition, its stimulating fibroblasts produce new collagen for a natural tissue lift and volumisation of one’s visage.


  • 100% polynucleotide (PN) gel
  • Derived from salmon DNA (bio-compatible PN gives the skin a younger, healthier appearance)
  • Formulated in Italy
  • Suitable for all skin types

The three variants of Nucleofill:


Nucleofill Soft 0.75%
  • 1.5ml glass vial
  • PH between 6.8 to 7.2
  • Viscosity: 28 to 43 PA*S
  • Two 30g 13mm needles included in each box
Nucleofill Medium 2%
  • 1.5ml glass vial
  • PH between 6.8 to 7.2
  • Viscosity: 28 to 43 PA*S
  • Two 30g 13mm needles included in each box
Nucleofill Strong 2.5%
  • 1.5ml glass vial
  • PH between 6.8 to 7.2
  • Viscosity: 48 to 65 PA*S
  • Two 30g 13mm needles included in each box

Ozhean Zoey caters to our patients’ needs with Nucleofill

At Ozhean Zoey, the concentration of polynucleotides to be used is chosen based on each and every patient’s needs and conditions. This is why we take the time to carefully assess every individual patient before offering a tailored Nucleofill treatment plan.

Nucleofill treatment needs to be repeated at least thrice, and every 15 to 30 days to be effective in the long term.


Nucleofill contains high molecular weight polynucleotide chains. These chains are highly viscoelastic and capable of binding a considerable amount of water molecules, resulting in:

The strong moisturising ability of Nucleofill lies in how it is an “electrostatic sponge” that confers deep hydration to tissues, thereby guaranteeing cellular well-being.

The polymeric molecules in Nucleofill act as an immediate “scavenger” against free radicals (unstable molecules that damage skin cells), resulting in immense protection and recovery of the skin.

The bio-restructuring and lifting effect is slow, continuous, and long-lasting.

All in all, Nucleofill promotes the metabolic activity of cells, and reintegrates fundamental components into the skin to restore and maintain youthful functionality.

The benefits of Nucleofill:

  • Intensely hydrates different layers of the skin
  • Has a long-lasting effect
  • Improves skin tone and texture
  • Increases skin elasticity
  • Reinvigorates cell function and activity
  • Strong lifting and anti-ageing outcomes
  • Allows for deep bio-remodelling and lifting effects

How does Nucleofill compare to other face lifting fillers?



Polynucleotide filler

HA fillers

PCL Filler

PLLA Filler

Face shaping results

Natural filling

Face lifting

Face shaping

Skin improvement is significantly notable

HA is very hydrophilic (tends to mix with, dissolve in, or be wetted by water), and may cause the face to look puffy after filling.

Ellanse has both Volumizing and Collagen-stimulating effects.

Skin improvement is significantly notable.

However, results may initially decline before it starts to increase over time.

Natural shaping

Face lifting

No. of sessions 3-4 sessions are needed for optimal results Only one session is needed Only one session is needed 3-4 sessions are needed for optimal results
How long do results last? After 3-4 treatments sessions, the results are long-lasting (at least 6 months)Depending on the degree of cross-linkage, results can last between 9 to 24 monthsWhile results can be very long-lasting, there might be some difficulty in predicting final outcomesLike Nucleofill, Sculptra is lasting if several sessions are done
Cost Lower compared to EllanseMedium cost, depending on volume High costHigh cost


Nucleofill is an effective solution for anyone who suffers from:

  • Asphyxial skin (skin lacking in oxygen)
  • Dehydrated skin
  • Stretch marks
  • Scars
  • Loose skin and poor circulation
  • Skin that is damaged by oxidative stress

As such, Nucleofill is an outstanding treatment solution for individuals who are looking to:

  • Rejuvenate and lift their skin
  • Look younger and healthier
  • Achieve a more vibrant complexion
  • Add more definition to their facial appearance
  • Regain overall skin health
  • Treat skin texture, tone, and elasticity issues


Before your treatment, your doctor will discuss and review your condition during a consultation session. At the start of the procedure, numbing cream will be applied to your face. Thereafter, the areas on your face that are to be injected will be marked. Finally, your doctor will proceed to perform injections of varying strengths to your desired areas.

Because Nucleofill is injected into the skin using a proprietary 7-point bio-restructuring technique, it allows for better cell stimulation within the deeper layers of the skin, leading to the reviving of the skin’s original youthful functions. This injection technique also allows for an additional lifting effect, resulting in not just a healthier appearance, but a more defined, contoured, and three-dimensional visage.

If a patient receives treatment once every 15-30 days, and for at least 3 consecutive sessions, they will experience continuous and significant improvement in the condition of their skin.

Within these timeframes, patients will experience specific changes in their skin:

  • 1-2h: Hydration and a swelling effect
  • 48h: Metabolic activation
  • 7-10 days: Enzymatic degradation
  • 15 days: Complete elimination

While the effects of Nucleofill might seem slow, remember that the many rejuvenation and skin lifting changes you will experience will last for a long time, and no less than a minimum of six months.

There is little to no downtime required after Nucleofill treatment. And while some individuals might notice bumps, minimal bruising, or slight swelling on their treated areas, these usually go away within a week.

Get in touch

    Email: enquiries@ozheanzoey.com

    Mon, Wed, Thu & Fri - 10:30 am to 7:30 pm

    Tue - 10:30 am - 6:30 pm

    Sat - 10:30 am - 4:30 pm

    Sundays & Public Holidays - Closed

    111 Somerset Road #04-10 TripleOne
    Somerset Singapore 238164

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