- Home
- About us
- Services
Skin
Face
Eyes
Body
- Treatments
Devices
Monolasers
Laser Programmes
Injectables
Others
- Products
- Blog
- Contact Us
Medical Precision,
Refined
Body Shaping
Non-surgical Approach
Fat Reduction
Featuring Cooltech Define
Personalised
& Natural Results
Personalised
& Natural
Results
Trusted by
10,000+ Patients
Trusted by
10,000+
Patients
Clinically
Proven Techniques
Clinically
Proven
Techniques
Re20 ECM Skin Booster in Singapore
The Korea-born treatment that is rewriting the future of skin rejuvenation
Across Gangnam's aesthetic clinics, one treatment has risen so quickly that it is reshaping how Korean doctors approach anti-aging: the ECM Skin Booster, and at the centre of this wave is Re20, Korea's widely talked-about ECM-restoring injectable.
Today, it is widely considered the dominant skin booster among Korean dermatologists. Instead of focusing only on hydration, glow or collagen, ECM skin boosters work on something much more foundational: the extracellular matrix (ECM), the "living skin infrastructure" that determines firmness, elasticity, radiance, and how young or old your skin behaves.
Meet Re20
The Treatment that Gives Your Skin Actual Good Skin.
Re20 isn’t just another skin booster — it is the primary ECM Booster made from real human-derived ECM (hADM).
That means it contains the exact components your youthful skin was naturally built with:
This is why Korean dermatologists call it: “Injecting (good) Skin… into Skin.”
It directly replaces what aging has taken away — not stimulating, not mimicking, but replenishing your dermal matrix with real ECM materials.
Re20 is the treatment many Korean doctors now pair with lasers, HIFU, RF, and regenerative procedures because it supercharges overall skin response. By strengthening the ECM, it enhances the results of almost every rejuvenation treatment, creating outcomes that are noticeably dramatic, longer-lasting, and naturally refined.
In fact, many clinics in Seoul now consider ECM skin boosters to be a core step of anti-aging, sitting alongside collagen devices and regenerative injectables as a main pillar of skin longevity care.
And now, this Korean sensation is available in Singapore at Ozhean Zoey, home of collagen-centred, Korean-inspired medical aesthetics.
Your skin is made of layers, but beneath the surface lies something far more important — the Extracellular Matrix (ECM). Think of the ECM as your skin’s internal support system. It is not a single structure, but a living network of collagen, elastin, hyaluronic acid, and proteins that hold your skin together.
In simple terms, the ECM decides how young, firm, smooth, and healthy your skin behaves.
The ECM keeps your skin lifted, firm and structured. When it weakens, skin starts sagging and collapsing.
The ECM keeps your skin lifted, firm and structured. When it weakens, skin starts sagging and collapsing.
Your collagen and elastin fibres live inside the ECM. If the ECM is damaged, these fibres can’t function — leading to wrinkles, laxity and dullness.
Your collagen and elastin fibres live inside the ECM. If the ECM is damaged, these fibres can’t function — leading to wrinkles, laxity and dullness.
The ECM holds growth factors that tell your skin when to heal, rebuild or regenerate.
The ECM holds growth factors that tell your skin when to heal, rebuild or regenerate.
Sun, stress, pollution and time break down the ECM. When the ECM collapses, aging accelerates — even if your skincare routine is good.
Sun, stress, pollution and time break down the ECM. When the ECM collapses, aging accelerates — even if your skincare routine is good.
Wrinkles, thinning skin, poor elasticity, fine lines, dullness — these are usually signs of ECM breakdown long before you can see it.
Wrinkles, thinning skin, poor elasticity, fine lines, dullness — these are usually signs of ECM breakdown long before you can see it.
Most treatments only target the surface or collagen. But to truly improve skin quality, you must target the ECM, the environment that controls how collagen, elastin and your skin cells function.
This is why ECM skin boosters like Re20 are so transformative; they strengthen the foundation of your skin, not just the surface.
Re20 is an innovative ECM Skin Booster from Korea formulated using a breakthrough material called human acellular dermal matrix (hADM), a micronized powder made from actual human skin ECM components.
This makes Re20 completely different from traditional skin boosters and collagen products that use hyaluronic acid alone or animal-derived collagen (such as porcine sources). Re20 uses real human-based ECM, giving it the closest match to youthful skin’s natural structure.
This defined composition mirrors the actual ECM profile found in youthful human skin.
Because the formulation comes from real ECM components, Re20 can integrate more naturally into the skin, helping:
In simple terms:
Re20 gives your skin the same core matrix it had in your 20s, restoring youth from the foundation up, not just the surface.
Every batch of Re20 undergoes a multi-step donor screening and purification process before it becomes an injectable Korean skin booster.
Lipids, units and DHT reduction are removed while the native proteins of the extracellular matrix skin components are preserved, so the collagen, elastin and GAGs that reach the dermis stay as close as possible to their natural form.
Re20 integrates into your dermal matrix
The high concentration of collagen (89%), elastin (3%) and other ECM proteins signals fibroblasts to produce new collagen and reorganise existing fibres — improving firmness and elasticity from within.
The glycosaminoglycans (GAGs), including hyaluronic acid, help retain moisture and support the movement of nutrients through the ECM.
Re20 integrates into your dermal matrix
The high concentration of collagen (89%), elastin (3%) and other ECM proteins signals fibroblasts to produce new collagen and reorganise existing fibres — improving firmness and elasticity from within.
The glycosaminoglycans (GAGs), including hyaluronic acid, help retain moisture and support the movement of nutrients through the ECM.
What Conditions & Areas
Can Re20 ECM Skin Booster Treat?
Because Re20 works on the extracellular matrix (ECM) — the foundation that controls firmness, elasticity, glow and skin behaviour — it improves multiple skin concerns at once, not just hydration.
Face
Neck
Décolletage
Cheeks
(volume quality, collagen renewal)
Cheeks
Under-eye area
(thinning skin, fine lines)
Under-eye area
Fine lines and early wrinkles
Uneven skin tone
Fine lines and early wrinkles
Uneven skin tone
Because Re20 supports the entire ECM, it improves overall skin behaviour — making the skin firmer, more elastic, and more youthful from the inside out.
Who Is Re20 ECM Skin Booster Suitable For?
Because Re20 is a medical injectable, suitability is always confirmed during your consultation. As a general guide:
You may be a good candidate if you have:
Fine lines, dullness or loss of firmness
Enlarged pores or rough texture
Early signs of elasticity loss or tired-looking skin
Skin that hasn't responded well to hydration-only treatments
Re20 may not be suitable if you are:
Pregnant or breastfeeding
Experiencing active skin infection or inflammation in the treatment area, such as an active acne flare, eczema flare or herpes outbreak
Immunocompromised or on certain medications
Known to have a severe allergy to antibiotics or antifungal medications used in processing, as trace residual amounts may remain
Why Korean Doctors Love
Re20 ECM Skin Booster
Re20 is widely used in Korea not only as a standalone rejuvenation treatment but also as a booster to enhance results from:
A stronger ECM makes all other treatments work with heightened efficiency, which is why Re20 is becoming a key anti-aging step in many established Korean aesthetic clinics.
Most side effects are gastrointestinal, mild to moderate, and concentrated while the dose is being raised. Our guiding rule is simple: the dose that works with the fewest side effects is the right dose.
Driven by slower stomach emptying, worst during dose increases. Controlled by titrating slowly, smaller lower-fat meals, and stopping at the first sign of fullness.
Re20 ECM Skin Booster Results
Because Re20 delivers real human-derived ECM components into the dermis, its benefits go far beyond glow or hydration. It improves how your skin behaves, not just how it looks.
Re20 ECM Skin Booster vs
Other Skin Boosters & Biostimulators
Re20 ECM Skin Booster vs Other Skin Boosters & Biostimulators
Today’s aesthetic injectables each serve a specific purpose. Hyaluronic acid improves hydration. Polynucleotides support cell repair. Biostimulators like PDLLA, PCL and CaHA build collagen. But none of these focuses on restoring completely the actual extracellular matrix (ECM) — the structure that holds collagen, elastin and HA together.
This is why Re20 stands apart. It is among the initial ECM skin boosters made from real human-derived ECM components, allowing it to rebuild the foundation of youthful skin, not just stimulate or hydrate part of it.
| What It Does | What It Cannot Do | Ideal For | |
|---|---|---|---|
| Re20 ECM Skin Booster | Rebuilds ECM structure with real human-derived collagen, elastin, GAGs; improves firmness, elasticity, density | Does not add volume | Full-face rejuvenation, skin quality, elasticity, foundational anti-aging |
| PN/PDRN | Repairs cells, reduces inflammation, improves healing | Does not rebuild ECM or strengthen collagen / elastin network | Sensitive skin, post-treatment recovery, under-eyes |
| HA Skin Boosters | Deep hydration, improved glow, smoother texture | Temporary; no structural or ECM regeneration | Dewiness, hydration, fine dehydration lines |
| PDLLA | Long-term collagen stimulation + light volumising | Does not replace elastin or ECM proteins | Volume restoration, deeper wrinkles |
| PCL | Strong collagen stimulation with long-lasting effects | ECM rebuilding mainly focuses on collagen | More volume restoration; Lifting, tightening, deeper firmness |
| CaHA | Collagen stimulation + firming effect | ECM rebuilding mainly focuses on collagen | Jawline, lower face firmness |
What to Expect During Your
Re20 ECM Skin Booster Appointment
What to Expect During Your Re20 ECM Skin Booster Appointment
Your doctor assesses your skin and confirms whether Re20 is the right fit for your goals.
The treatment area is cleansed and numbing cream is applied to keep the session comfortable.
Re20 is delivered into the superficial dermis through fine micro-injections, mapped across the treatment area.
You'll receive clear guidance on what to avoid and when you can resume your usual skincare routine.
Your doctor assesses your skin and confirms whether Re20 is the right fit for your goals.
The treatment area is cleansed and numbing cream is applied to keep the session comfortable.
Re20 is delivered into the superficial dermis through fine micro-injections, mapped across the treatment area.
You'll receive clear guidance on what to avoid and when you can resume your usual skincare routine.
Aftercare
After Your Re20 ECM Skin Booster Treatment
Downtime is minimal, but the following guidance helps your skin get the most out of its extracellular matrix skin restoration.
In the first 24 to 72 hours
A Korean board-certified dermatologist and founder of the Ozhean Skin and Plastic Surgery Network, she has authored over 30 scientific papers and created the SKIN FIT program, which has helped over 20,000 patients achieve radiant, healthy skin. She believes in personalised, evidence-based treatments that enhance natural beauty and is proud to bring the Ozhean philosophy to Singapore.
A seasoned aesthetic physician with a strong surgical foundation, he has over 15 years of medical experience spanning multiple subspecialties. Trained under the National Healthcare Group and holding postgraduate surgical qualifications, his practice is grounded in precision, anatomical accuracy, and safety. He focuses on facial harmony, structural refinement, and collagen-based regenerative treatments, with a philosophy centred on thoughtful decision-making, conservative execution, and long-term, natural ageing.
A dedicated physician with a background in family medicine, ENT, anaesthesia, dermatology, and aesthetic medicine. With experience in clinical dermatology, facial reconstruction, and collagen-based treatments, he focuses on anti-aging and long-term skin health. He believes in personalised and holistic care, combining medical expertise with artistic sensibility to support each patient’s confidence and well-being.
Dr. Tan Jun Yang is an aesthetic physician with a clinical background spanning Cardiothoracic Surgery, Anaesthesia, General Surgery, and Dermatology. His time at the National Heart Centre Singapore and the National University Hospital Heart Centre gave him extensive surgical training in complex heart and lung conditions as well as post-operative reconstructive procedures, a depth of experience that allows him to deliver results with confidence, consistency, and the utmost commitment to safety.
Most patients notice improvements within 1–2 weeks, especially in skin texture and hydration. Full ECM rebuilding effects — increased firmness, elasticity and density — continue to improve over 4–8 weeks as collagen and elastin fibres reorganise.
Clinical data (NCT07155278) shows progressive ECM strengthening up to several weeks after treatment.
Results typically last 6–12 months, depending on age, skin quality and lifestyle. Because Re20 works on the structural ECM layer, its benefits are longer-lasting than HA-only skin boosters.
Some Korean clinics report sustained improvement even beyond 12 months due to ongoing collagen remodelling.
For optimal ECM restoration:
Initial protocol: 1 session every 4 weeks for 2 sessions
Maintenance: 1 session every 6–12 months
(This is consistent with Korean dermatology protocols.)
Discomfort is minimal. Re20 is delivered into the superficial dermis using fine micro-injections, and numbing cream is applied beforehand. Patients usually describe it as light pressure or small pinpricks.
Very minimal. Most patients return to daily activities immediately. Small bumps from the ECM particles settle within a few hours to a day. Makeup can typically be applied the next day.
Yes — and this is one reason ECM Skin Booster is widely popular in Korea. Re20 strengthens the ECM, which enhances the results of:
Korean doctors often use Re20 as a booster to make other treatments work with increased effectiveness and last longer.
Pricing varies depending on treatment area and number of syringes used. In Singapore, the price generally starts from $950 - $1,200 per session. At Ozhean Zoey, your doctor will advise the appropriate amount based on your skin condition.
A single Re20 syringe typically contains enough product to treat the full face in one session. Your doctor will confirm the exact number of syringes needed based on your treatment area and skin condition.
Re20 is processed to remove cells and DNA residues, but trace amounts of antibiotics or antifungal agents used during purification may remain. If you have a known severe allergy to these types of medications, let your doctor know beforehand so your suitability can be properly assessed.
Contact the clinic promptly if you experience worsening pain, skin colour changes, blistering, fever or rapidly increasing swelling after your Re20 ECM Skin Booster session.
111 Somerset Road #04-12/13/14 TripleOne Somerset Singapore 238164
Mon, Wed, Thu & Fri - 10:30 am to 7:30 pm
Tue - 10:30 am - 6:30 pm
Sat - 9:30 am - 6:30 pm
Sundays & Public Holidays - Closed
© All rights reserved
