In the fast-paced and beauty-conscious landscape of Singapore, skin booster treatments have rapidly gained popularity as one of the effective ways to achieve swift, noticeable improvements in skin health. These minimally invasive procedures complement other aesthetic therapies such as laser and radiofrequency (RF) treatments, providing hydration, rejuvenation and anti-ageing benefits. The demand for skin boosters reflects Singaporeans' growing preference for non-surgical aesthetic solutions, which offer tangible results with minimal downtime. With an average session costing between SGD 300 to SGD 800, skin boosters represent a valuable investment for individuals keen on maintaining youthful, glowing skin.

How Do Skin Boosters Work

Skin boosters rejuvenate the skin by introducing specialised active ingredients such as hyaluronic acid (HA), Poly-D, L-lactic acid (PDLLA), and Polynucleotide (PN) directly into the skin’s deeper layers. This targeted delivery method ensures effective absorption and effectiveness, improving hydration, collagen production, and overall skin health.

These injections are typically administered manually using ultra-fine needles (32-34 gauge), minimising discomfort. Alternatively, injector guns equipped with multiple needles can be used for quicker procedures, albeit with a slightly higher risk of leakage. Both methods maintain very low pain scores, and local anaesthetics are commonly applied to further enhance patient comfort. Individuals with heightened sensitivity may opt for additional pain relief measures to ensure a pleasant treatment experience.

The three primary ingredients used in skin boosters each have distinct roles:

• Hyaluronic Acid (HA): An essential hydration molecule, HA attracts water to intensely moisturise the skin, visibly improving elasticity and texture.
  
• PDLLA (Poly-D, L-lactic Acid): A powerful biostimulator, PDLLA promotes the production of collagen and elastin, essential proteins for maintaining skin firmness and elasticity.
  
• Polynucleotide (PN): Derived from DNA compounds, PN primarily facilitates skin repair and reduces inflammation, making it effective for rejuvenating damaged skin.
  

Where Can Skin Boosters Be Used?

One of the major advantages of skin boosters is their versatility. These treatments effectively target multiple areas, delivering results across different regions of the body:

• Face: Skin boosters improve skin tone, hydration, and elasticity on areas such as the forehead, cheeks, under-eye regions, and jawline, diminishing fine lines and wrinkles.
  
• Neck: They enhance neck firmness and elasticity, combating signs of ageing that often manifest prominently in this delicate area.
  
• Hands: The rejuvenating effects restore hydration and plumpness, making hands appear younger and less susceptible to ageing signs.
  

Patients who undergo skin booster treatments notice substantial improvements across these areas, achieving visibly revitalised skin and an overall younger appearance.

Different Types of Skin Boosters

Hydration Series

The Hydration Series primarily features HA, known for its moisture-retention properties. Clinical studies (PMC10082573) demonstrate that HA significantly boosts the skin’s hydration levels, enhancing elasticity and reducing fine lines. This intense hydration improves the skin’s structural support and extracellular matrix (ECM), resulting in more youthful skin.

There are two main HA-based skin boosters:

• Non-cross-linked HA: Provides faster, intense hydration with visible effects lasting approximately 2-3 months.
  
• Mildly cross-linked HA + Glycerol (Belotero Revive): Scientifically proven (PubMed35070607; PMC6698156) to offer lasting results of up to 9 months, delivering sustained hydration, improved skin texture, and longer-lasting rejuvenation effects.
  

Collagen Series

Collagen boosters such as PDLLA enhance the skin’s natural ability to produce collagen, leading to improved firmness and elasticity. Studies (PubMed37969055; PubMed37175693) confirm improvements in skin texture, volume, and overall firmness, specifically highlighting the effectiveness of Juvelook in achieving lasting skin rejuvenation. Regular treatments result in firmer and younger-looking skin.

Healer Series

The Healer Series, featuring Polynucleotide (PN), specialises in skin repair and rejuvenation. PN’s powerful regenerative properties effectively target damaged skin, particularly from acne scarring or photodamage. Clinical research (PMC11311621) highlights PN’s ability to rejuvenate damaged skin, reduce inflammation, and enhance skin healing. Although its primary strength lies in repair, PN also moderately contributes to collagen production and hydration.

Comparative Table of Skin Boosters

Feature	Hydration Series (HA)	Collagen Series (PDLLA)	Healer Series (PN)
Primary Effect	Intense hydration	Collagen stimulation	Skin repair and anti-inflammatory
Duration	2-9 months	12-18 months	6-12 months
Ideal for	Dry, dehydrated skin	Ageing, sagging skin	Acne-prone, damaged skin
Secondary Benefits	Improved elasticity, glow	Enhanced skin firmness, texture	Reduced redness, improved healing

Who Is Suitable for Skin Boosters?

Skin boosters are beneficial for a broad range of individuals. They are especially suited for those experiencing skin dehydration, mild sagging, fine lines, and imperfections such as acne scars. These treatments are gentle enough to accommodate sensitive skin types, making them accessible to almost everyone seeking improved skin health and appearance.

What to Expect During and After a Skin Booster Injection Treatment

The Skin Booster Injection Procedure: Step-by-Step

The skin booster injection procedure is relatively quick and straightforward:

1. Consultation: Your aesthetic doctor will assess your skin, discuss your goals, and recommend the best type of treatment.
2. Preparation: To minimise discomfort during the procedure, the treatment area will be cleaned and numbed with a topical anaesthetic.
3. Injection: The doctor will inject the skin booster into the intended areas using a fine needle. Depending on the treatment area, multiple tiny injections may be required.
4. Post-Treatment Care: After the injections, your skin may appear a little red or swollen, but these effects typically subside within a few hours.

The entire procedure spans between 30 to 60 minutes, depending on the area being treated.

Aftercare Tips and Post-Treatment Recovery

After your skin booster injection, follow these aftercare tips to ensure lasting results:

• Avoid touching or rubbing the injected site for at least 24 hours to prevent irritation.
• Stay out of direct sun exposure for 48 hours to reduce the risk of sunburn or pigmentation.
• Keep the treated area clean and follow instructions from your doctor for skin care.

You may see slight redness, swelling, or bruising, but these side effects typically resolve within a few days. There’s minimal downtime, so you can resume most of your regular activities after treatment.

How Long Does It Take to See Results from Skin Booster Injections?

You can expect initial results to be noticeable within 1–2 weeks after your treatment as your skin absorbs the hyaluronic acid and becomes more hydrated. Full results will gradually develop over the following weeks as collagen production picks up and skin texture improves.

For long-lasting benefits, we recommend maintenance treatments every 6 to 12 months, depending on the type of skin booster used and your skin concerns.

Can You Combine Different Skin Booster Products?

Absolutely. Combining various skin boosters amplifies their effects through synergistic actions:

• PDLLA + HA: Offers enhanced hydration alongside robust collagen stimulation, resulting in firmer, radiant skin.
  
• HA + PN: Particularly effective for acne-damaged skin, this combination provides intensive hydration and potent repair, as clinically supported (PubMed32248707), rejuvenating even severely affected skin.
  

The OZ Difference

At Ozhean Zoey Medical Clinic, we design various skin booster combinations for skin rejuvenation:

• Zoey Skin Combo (HA + PN + Botulinum + Tranexamic Acid): Targets multiple concerns, including pore reduction, skin whitening, and texture refinement.
  
• Baby Collagen (Type 1 Collagen + HA): Ensures deep hydration, enhanced skin repair, and improved skin firmness and elasticity.
  
• Mixed HA Protocol (Non-cross-linked HA + Cross-linked HA/Glycerol): Delivers both fast and prolonged hydration, effectively rejuvenating the skin.
  

Consult Ozhean Zoey Medical Clinic

Ready to experience the transformation skin boosters offer? Schedule your personalised consultation with Ozhean Zoey today and embark on your journey towards youthful, radiant, and healthier skin.

Collagen has long been celebrated as the foundation of youthful, healthy skin. As we age, collagen production in our bodies naturally declines, leading to visible signs of ageing such as fine lines, wrinkles, and sagging skin. In Singapore, where the demand for non-invasive aesthetic treatments is on the rise, collagen-based therapies have gained immense popularity for their ability to rejuvenate the skin and restore its natural glow. This comprehensive guide will help you understand the differences between collagen injections and collagen biostimulators, explore the history and science behind these treatments, and provide practical insights on choosing the right treatment for your needs.

What Is Collagen and Why Does

Collagen is the most abundant protein in the human body, making up around 30% of our total protein content. It provides structure and strength to our skin, bones, muscles, and connective tissues. In the skin, collagen gives firmness and elasticity—two key elements that contribute to a youthful appearance. Unfortunately, starting from our mid-20s, collagen production begins to slow down, and by the time we reach our 40s, we may have lost up to 25% of our skin’s collagen. This decline results in wrinkles, sagging, and a loss of volume.

To combat these effects, aesthetic medicine has developed various collagen-enhancing treatments. Among them, collagen injections and collagen biostimulators are two of the most talked-about options. Although both aim to improve collagen levels in the skin, their mechanisms, benefits, and treatment goals differ significantly.

Collagen Injections vs Collagen Biostimulators: Understanding the Difference

Collagen Injections

Collagen injections involve the administration of collagen-based products directly into the skin. These products contain processed collagen—either from bovine, porcine, or other sources—and are designed to restore volume, smooth out fine lines, and stimulate the body’s own collagen production. Historically, the earliest collagen injections used bovine-derived products like Zyderm and Zyplast. However, these were phased out due to allergic reactions and the short duration of effect.

Modern collagen injections have evolved significantly. Products such as Linerase and Deusaderm are designed to minimise allergic reactions while maximising regenerative potential. Linerase, for example, is a porcine-derived type I collagen that has undergone specific processing to reduce allergenicity. It is effective for superficial skin rejuvenation and is widely known in Singapore as the “baby collagen” treatment due to its ability to restore a soft, youthful texture to the skin.

Deusaderm, on the other hand, is a collagen filler made from porcine dermis. It uses technologies such as telopeptide removal, multifiber induction, and dual cross-linkage to mimic the properties of human collagen without the need for human tissue sourcing or donor screening. When used undiluted, Deusaderm acts as a filler for areas like tear troughs, delivering natural volume and contour. When diluted, it becomes a skin booster that enhances dermal quality and radiance.

Collagen Biostimulators

Collagen biostimulators are synthetic polymers that do not contain collagen themselves. Instead, they work by stimulating the skin to produce its collagen over time. These compounds include substances like poly-L-lactic acid (PLLA), poly-D, L-lactic acid (PDLLA), and polycaprolactone (PCL). Once injected, they create a mild inflammatory response that activates fibroblasts, the cells responsible for generating collagen.

Unlike collagen injections, which offer relatively immediate results, biostimulators take weeks to months to show their full effect. However, their results are often longer-lasting, with some products offering benefits for up to two years. Biostimulators are typically used for deeper facial volumization, structural lifting, and correcting age-related skin laxity.

The History of Collagen Injections: From Bovine to Bioengineered Breakthroughs

The use of collagen as a dermal filler dates back several decades. According to a study published in the Journal of Clinical and Aesthetic Dermatology, Zyderm and Zyplast were among the first bovine collagen fillers approved for aesthetic use. While effective, they required mandatory skin testing due to the risk of allergic reactions, and their results typically lasted only a few months.

In an effort to improve safety and longevity, researchers began exploring human-derived collagen. These included collagens extracted from human placentas, which had zero allergenic potential. However, the requirement for stringent infectious disease screening and regulatory approval limited their widespread adoption. Since 2005, no human-derived collagen filler has received global licensing in many countries.

This led to the development of new-generation collagen products like Linerase and Deusaderm. Linerase is a heterologous collagen with hypoallergenic properties, making it ideal for skin regeneration and anti-ageing treatments. Deusaderm, derived from porcine skin and enhanced through proprietary processing techniques, provides a close approximation to human collagen while eliminating the need for donor screening. Both products represent an advancement in the field of bioregenerative aesthetics.

Comparing Efficacy: Collagen Injections vs Biostimulators

While there is no direct clinical study comparing the efficacy of collagen injections versus collagen biostimulators, expert experience in the field provides valuable insights. For instance, collagen biostimulators such as PCL and PDLLA are often preferred for patients seeking deep volume restoration, particularly in the midface, temples, and jawline. These products offer long-term collagen production and a gradual, natural-looking lift.

Collagen injections, by contrast, are ideal for more superficial applications. Deusaderm, for example, is highly effective in correcting tear trough deformities and under-eye shadows with minimal swelling and a 95% correction rate. It provides an excellent alternative to hyaluronic acid (HA) fillers, especially in patients prone to puffiness or Tyndall effect.

In terms of skin quality improvement, older patients may benefit more from collagen injections like Linerase, which help restore a thinning dermis and improve skin texture. PDLLA skin boosters are often used for younger patients dealing with acne scars and enlarged pores, offering mild collagen stimulation and skin refining effects.

Not Just Injections: Devices That Act as Collagen Biostimulators

While injectables are widely recognised for their biostimulating effects, certain medical devices have also proven to be effective collagen boosters. These technologies deliver energy to the deeper layers of the skin, stimulating natural collagen production through heat or mechanical action.

1. High-Intensity Focused Ultrasound (HIFU)

HIFU, including advanced versions such as Ulthera and Ozhean’s proprietary Ultherma, works by delivering focused ultrasound energy into the SMAS (Superficial Musculoaponeurotic System) layer of the skin. This energy heats the tissue to a precise temperature, triggering a wound healing response that results in collagen production and skin tightening. The effect is a natural lift without surgery.

2. Radiofrequency Microneedling (RF-MN)

Devices like Secret RF and Sylfirm X combine microneedling with radiofrequency energy. The microneedles create controlled micro-injuries in the skin while delivering heat deep into the dermis. This dual action promotes both skin renewal and collagen induction, making RF-MN ideal for acne scars, enlarged pores, and fine lines.

3. Laser Devices

Certain fractional and non-ablative lasers also stimulate collagen by heating the dermis. Technologies such as the Mulgwang Laser or Pento Laser used at Ozhean Zoey promote brightening and collagen renewal with minimal downtime. These treatments are particularly useful when combined with injectable collagen therapies for a synergistic effect.

Why Singapore Is Turning to Collagen Therapies

In Singapore’s fast-paced and appearance-conscious society, there is a growing demand for aesthetic treatments that are safe, effective, and deliver natural results with minimal downtime. Collagen therapies fit this demand. They offer a regenerative approach to skincare, focusing on rebuilding the skin’s natural structure rather than simply masking imperfections.

Clinics such as Ozhean Zoey have built a reputation for specialising in collagen-based protocols. Their approach involves combining injectables with supportive technologies like ultrasound-based lifting, laser systems, and exosome therapy to maximise results.

Frequently Asked Questions About Collagen Treatments

Final Thoughts: Choosing the Right Treatment for You

Collagen-based therapies can help anyone seeking natural rejuvenation, volume restoration, and skin refinement. Whether you choose a collagen injection like Linerase or Deusaderm, or opt for a long-lasting biostimulator such as PCL or PDLLA, the key lies in personalised treatment planning. Each modality serves a different purpose: collagen injections are ideal for delicate, superficial applications, while biostimulators are ideal for deep lifting and long-term collagen regeneration.

At Ozhean Zoey Clinic, we pride ourselves on our commitment to collagen science. Our doctors carefully assess your skin condition, age, and aesthetic goals to craft a tailored treatment plan that combines collagen injections, biostimulators, and adjunct therapies. If you're considering collagen therapy in Singapore, book a consultation with us to discover what approach will bring out your skin’s potential.

In the world of aesthetic treatments, Ultherapy has long held the crown as the gold standard in non-surgical skin lifting. Since gaining FDA approval in 2009, Ultherapy has become the trusted solution for those seeking to tighten and lift their skin without surgery or downtime. Its reputation has been built not only through clinical studies but also thanks to endorsements from celebrities, influencers, and doctors alike.

Recently, Ultherapy Prime, an upgraded model, was launched and quickly took the aesthetic industry by storm. Developed by Merz Aesthetics, this newest version boasts significant improvements. It delivers faster treatments, more efficient energy delivery, and, most importantly, more accurate imaging, which allows for greater precision. In clinical experience so far, patients overwhelmingly report that Ultherapy Prime is more comfortable and tolerable than the original Ultherapy, offering an elevaated patient experience.

Among Ultherapy Prime’s biggest fans is Korean superstar Lee Min Ho, whose sculpted, natural appearance has become the ideal that many men aspire to. As the face of Ultherapy Prime for Korean men, Lee Min Ho represents a growing demographic: men seeking subtle, non-surgical ways to maintain youthful, firm skin and bank collagen for the future.

Are More Men Becoming Interested in Cosmetic Procedures?

It’s no secret that women have traditionally made up the majority of cosmetic procedure patients. But that’s changing. According to a 2024 study published in PMC (PMC11379790), there has been a significant rise in men seeking cosmetic treatments over the past decade. While they still represent a smaller percentage of the overall market, the rate of increase in male patients is faster than that of women. Men today are increasingly aware of the benefits of maintaining their appearance, especially in competitive professional and social environments.

A separate study (PubMed ID 37956742) explored men’s attitudes towards cosmetic procedures and their pain tolerance. Interestingly, while men often express more concern about discomfort and recovery time, this lower pain threshold actually makes them ideal candidates for non-invasive treatments like Ultherapy Prime, which offers minimal discomfort and no downtime. The study also found that most men prefer non-surgical treatments over more invasive procedures, as they wish to avoid potential side effects, long recovery periods, and scarring.

Men today are not necessarily looking to appear dramatically younger. Rather, they want to look rested, healthier, and confident without obvious signs of having had aesthetic treatments. Ultherapy Prime fits perfectly into this philosophy.

 

Male vs Female Face: Why Men Need a Different Approach

It’s important to recognize that male facial anatomy is different from women’s. This impacts both how aging appears and how treatments should be performed.

Research confirms that men’s skin is roughly 20-25% thicker than women’s skin. It also contains higher collagen density, which gives male skin a firmer, more resilient quality. However, this thickness can also mean that certain superficial treatments are less effective on men than on women.

Additionally, men generally have less subcutaneous fat in the face, especially in the cheeks. This results in a more angular, defined appearance but also means that any skin sagging or volume loss becomes noticeable more quickly. Male muscle mass is also higher, particularly in the jaw and temple areas, contributing to stronger contours.

Most importantly, aesthetic surveys and studies (including research from Harley Academy and the American Academy of Facial Plastic Surgery) reveal that men prefer subtle enhancements. They want to look more rested and refreshed—not dramatically altered. While women often seek volumization or contour changes, men prioritize maintaining their natural masculine features.

This makes men excellent candidates for skin-tightening treatments like Ultherapy Prime, which offer gradual, natural-looking improvements without adding volume or dramatically altering facial structure.

 

How Does Ultherapy Work — And Why Is Ultherapy Prime More Ideal?

Ultherapy works by delivering micro-focused ultrasound energy deep beneath the skin’s surface, targeting the Superficial Musculoaponeurotic System (SMAS) layer. This is the same foundational layer tightened during surgical facelifts. By stimulating collagen production at this depth, Ultherapy creates a lifting and tightening effect over the course of several months.

What sets Ultherapy Prime apart is its modern visualization technology. The device includes real-time imaging, allowing the practitioner to see exactly where the energy is being delivered. This ensures that treatment is accurately targeted, avoiding superficial or ineffective shots and ensuring consistent results.

Compared to older Ultherapy models, Ultherapy Prime also offers:

• Faster treatment times (20% quicker than before)
• Sharper and more accurate imaging
• Enhanced ergonomics for higher patient comfort
• Less discomfort, as reported consistently by patients across clinics, including Ozhean Zoey

For men, these improvements mean a more tolerable experience and results, even with their thicker skin and unique facial structures.

 

What Results Can Men Expect with Ultherapy Prime?

Ultherapy Prime offers men subtle but meaningful improvements. After treatment, many men notice:

• Smoother smile lines and fine lines, especially around the eyes and mouth
• A more lifted and rested appearance, particularly in the jawline and lower face
• Refined neck tightness, which is essential because the neck often shows early signs of aging and is considered an extension of the face
  

Unlike fillers or volumizing treatments, Ultherapy does not add fullness to the face. This is particularly important for men, as added volume can feminize the face or distort natural masculine features.

Additionally, Ultherapy Prime appeals to men because it avoids the risks and side effects associated with more invasive procedures, such as thread lifts or surgical facelifts. There’s no risk of scarring, minimal discomfort, and no required downtime.

 

Enhancing Results: What Other Treatments Should Men Consider?

While Ultherapy Prime is powerful on its own, the ideal results often come from combining treatments. For men seeking a fully refreshed yet natural appearance, the following are excellent additions:

1. Skin Boosters 
   Skin boosters hydrate the skin from within and enhance collagen production, further improving skin elasticity and reducing fine lines.
2. Botulinum Toxin
   Carefully placed botulinum toxin injections can reduce dynamic wrinkles, such as forehead lines, frown lines, and crow’s feet, without freezing the face or making it look unnatural.
3. Collagen Biostimulators
   For those wanting even more support for their skin’s collagen network, biostimulators can be combined with Ultherapy Prime to provide long-term improvement in skin firmness and texture.
   

These combinations can be tailored to a man’s individual goals, ensuring natural-looking rejuvenation without downtime or dramatic changes.

 

Clinical Experience at Ozhean Zoey: Ultherapy Prime for Men

At Ozhean Zoey Medical & Aesthetic Clinic, part of the Genuine Aesthetic Medical Group from Gangnam, Korea, we have treated many male patients with both Ultherapy and Ultherapy Prime. Our clinical observations have consistently shown that:

• Male patients overwhelmingly prefer Ultherapy Prime to the older Ultherapy model.
• Discomfort is significantly lower, which is important given men’s lower average pain tolerance.
• Treatment times are faster, which busy male professionals appreciate.
• Natural-looking results are achieved without compromising masculine facial structure.

Our Group Medical Director, Dr. Park Ji-youn, is a recognized leader in the field and a member of the Global Aesthetic Leaders Club for Ultherapy Prime. Her extensive experience ensures that each treatment is customized to suit the unique anatomical features and aesthetic goals of our male patients.

 

Cost Considerations: Ultherapy Prime vs Ultherapy

Ultherapy Prime does come at a slightly higher price point than the original Ultherapy—typically about 5-10% more, depending on the clinic and treatment area. However, most male patients find the added comfort, efficiency, and enriched results to be well worth the modest price increase.

Feature	Ultherapy	Ultherapy Prime
Visualization	Yes	Enhanced, sharper, faster
Treatment Time	Standard	20% faster
Patient Comfort	Moderate	Significantly refined
Results	Strong lifting results	Enhanced precision & results
Cost	Base price	5-10% higher

 

Final Thoughts: The Smart Choice for Men

Ultherapy Prime is the ideal skin lifting treatment for men who want subtle, natural-looking rejuvenation without surgery. It respects the unique qualities of male facial anatomy, avoids adding volume, and offers results that enhance confidence without compromising masculinity.

If you’re a man seeking a refreshed, lifted appearance that looks completely natural—and you prefer treatments with minimal discomfort, no downtime, and proven results, then Ultherapy Prime should be at the top of your list.

 

Ready to Look Rested and Confident?

At Ozhean Zoey Medical & Aesthetic Clinic, we specialize in personalized aesthetic treatments for men. Whether you’re interested in Ultherapy Prime alone or a combination treatment plan, our team led by Dr. Park Ji-youn will tailor your care to achieve the ideal results.

Contact us today to schedule a private consultation and discover how Ultherapy Prime can help you achieve a refreshed, confident appearance — without surgery.

Considering the Singaporean climate, weather conditions, and lifestyle, the way that the body produces collagen can greatly vary from one individual to another. This is where collagen stimulators can work their wonders, and with today’s advancements in the field of aesthetic treatments, you’ll be surprised as to how they can help you achieve healthy, youthful skin with no hassle or downtime. 

In this article, we'll thoroughly dive into how to achieve youthful skin through understanding how collagen stimulators work and why it goes beyond just a dedicated skincare routine. 

 

What Determines Healthy, Youthful Skin?

No blemishes, no pimples, no discolorations - these are the most obvious indicators of having healthy skin. However, healthy skin is more than just how it looks on the outside, but also how it functions on the inside. To keep things straightforward, here are the key factors that define healthy skin:

• Hydration - For the skin to keep its elasticity and smoothness, a constant moisture supply is highly essential.
• Skin Cell Turnover - Healthy skin means that it regularly renews itself by shedding dead skin cells and generating new, healthy ones to maintain the skin’s youthful state.
• Barrier Strength - It helps keep the good stuff (like moisture and nutrients) in and the bad stuff (like pollutants and irritants) out.
• Oil and Water Balance - This can be quite crucial, especially in humid places like Singapore, where the weather contributes to sebum production.
• Collagen and Elastin Levels - These abundant proteins play a role in keeping the skin firm and plump.

Unfortunately, due to many factors like the environment, lifestyle choices, and the natural aging process, these functions that keep the skin healthy tend to be disrupted. In the goal of achieving youthful skin, elasticity and firmness in the skin are vital — this is where collagen stimulators come into play. Regenerative treatments targeting collagen production will help revive your skin’s natural processes from within. But what exactly are “Collagen Stimulators”?

 

What Are Collagen Stimulators?

Collagen stimulators are aesthetic treatments that are specifically designed to boost your skin’s collagen production naturally. They help the skin produce collagen instead of just artificially adding volume or filling the lines on your skin like traditional dermal fillers. Since they work together with the natural processes in your skin, results may not always be visually instantaneous. However, collagen stimulators are generally deemed as a healthier option as they work gradually from within by encouraging your body to rejuvenate and reinforce that skin’s supportive structure. 

The best thing about collagen stimulators? They result in firmer, softer, and healthier skin that lasts longer compared to the short-lived effectiveness of traditional dermal fillers. Think of them as “skin fitness trainers” as they help “train” and stimulate your skin to regenerate collagen on its own.

Collagen stimulators can be delivered through:

• Energy-based devices (Non-invasive) or 
• Injectables 

Both activate fibroblasts to significantly promote collagen production. The treatments can slightly vary from one another, but they all share the same objective of stimulating the skin’s collagen synthesis and triggering a natural healing response that will make the skin firmer and more youthful. 

In Singapore, these collagen-stimulating treatments have been gaining more popularity in recent years due to their compatibility with the Singaporean climate and lifestyle. But then, how do you know which specific treatment is for you? Let us guide you through these collagen stimulators.

 

Non-invasive Treatments For That Youthful Glow

For those who don’t want to deal with surgery, needles, and downtime, here are three non-invasive collagen-stimulating treatments you can consider getting. These collagen stimulators work by delivering energy deep into the skin to trigger a collagen-producing response. As they work by helping the skin renew itself naturally over time, visible results may take a few sessions. The great news is that this also means long-lasting results.

 

Ultherapy Prime

If you’re looking for a medical-grade face-lifting treatment, Ultherapy Prime in Singapore is something you may want to consider. This involves highly modern ultrasound technology plus a real-time imaging system to tailor the treatment specifically for your facial anatomy. It uses an upgraded device that delivers targeted ultrasound energy to boost collagen and elastin production for firmer, tighter, and more radiant skin. It’s a non-invasive procedure, so you also won’t experience any downtime, but because it involves the delivery of ultrasound energy, you may experience slight tingling and warmth. 

• Who is it best for: Individuals who want to treat a wide variety of skin aging problems, like wrinkles and fine lines. It’s also advisable for those who want to have a more contoured facial shape.
• Longevity: Can last up to 1 year or more. This can vary from one individual to another.

 

10Therma

10Therma uses Monopolar Radiofrequency technology by delivering controlled levels of high heat to promote collagen production and regeneration. This technology helps boost your skin’s collagen levels to give a significant lifting effect that lasts a long time. 10Therma is comfortable and treats a wide variety of skin issues without any worries about experiencing downtime.

• Who is it best for: Individuals who experience volume loss in the face, specifically in the areas around the jawline and neck.
• Longevity: Up to 12 months

 

Long Pulse Laser

Laser treatments have been around for decades, and they’re still one of the most familiar options for those seeking to target different kinds of skin concerns. It’s also a collagen stimulator, but aside from promoting collagen production to improve firmness and elasticity, the Long Pulse Laser also addresses redness, dull skin, acne scars, and pigmentation. The laser energy targets blood vessels and breaks down pigment clusters to achieve more radiant, clearer skin.

• Who is it best for: Individuals who want to target sagging skin and pigmentation problems. Taking regular sessions as advised by the doctor can also help deal with pitted acne scars and heal them over time. 
• Longevity: Lasts up to 6 to 12 months.

 

Take a look at this comparison table to see how each device works and what it targets:

Treatment Name	Key Technology	Targeted Skin Layer	Why It Targets That Layer
Ultherapy PRIME	Micro-focused Ultrasound with DeepSEE visualization	Deep dermis to Superficial Musculoaponeurotic System (SMAS)	Delivers ultrasound energy to foundational layers for collagen stimulation and skin lifting without surgery.
10Therma	Monopolar Radiofrequency (RF) with Smart Temperature Cooling System	Mid to deep dermis	Uses controlled RF to uniformly heat the dermis, promoting collagen regeneration and improving elasticity.
Long Pulse Laser	Long-pulsed CO₂ laser technology	Epidermis to mid-dermis	Targets superficial skin layers to reduce pigmentation, improve tone, and stimulate collagen.

 

Injectables For Firm, Radiant Skin

Collagen stimulators in the form of injectables aren't just like the traditional dermal fillers most of us know. They are biostimulating fillers that restore the skin’s natural volume while also stimulating new collagen formation in the skin. Each type of these injectables features unique formulas tailored to cater to different kinds of skin concerns. Here’s a quick guide on everything you need to know about these injectables — their key ingredients, who they are for, their effect, and how long they would last.

 

PDLLA Filler (Poly Lactic Acid + Hyaluronic Acid)

This type of injectable is also known as PDLLA Collagen Stimulator in Singapore. It helps in repairing damaged skin by having the combination of PLA and Hyaluronic Acid to repair and rejuvenate the skin tissue. This uniquely formulated filler typically delivers strong results right after the injection, giving you that youthful volume and radiance.

• Who is it best for: Individuals who need deep structural support, such as those suffering from scarring, sagging skin, or tissue damage.
• Longevity: Lasts up to 2 years

 

PDLLA Skin Booster (Poly D-Lactic Acid + Hyaluronic Acid)

It may have the exact same abbreviations as the previous filler we talked about, but they do differ in terms of components and effects. This one is a “skin booster” rather than a “filler,” which aims to bring moisture into the skin for a plumper appearance. The PDLLA Skin Booster features a hybrid formula that focuses on producing and “banking” collagen. This doesn’t add as much volume as the others in this list because it focuses more on deep hydration and collagen stimulation to help reverse signs of aging. 

• Who is it best for: Individuals who want to address fine lines, enlarged pores, and minor scarring. It also suits those who want an additional, natural glow.
• Longevity: Lasts up to 2 years

 

PCL Filler (Poly-Caprolactone)

This injectable is also known as Regenerative Volumising Dermal Filler in Singapore. It involves gel and microspheres that work in complete synergy to stimulate the body’s natural collagen production process. What sets it apart is the fact that it works by triggering a response that results in long-term collagen production, making its anti-aging benefits last long.

• Who is it best for: Individuals who have deeper lines and wrinkles who wants to achieve quick volumizing effect. This is also a great choice for those looking for a more tailored anti-aging treatment plan.
• Longevity: Long-lasting result up to 2 years. It can even last longer when done regularly, as advised by the doctor.

 

CaHA Filler (Calcium Hydroxylapatite)

If you’d like to bring back your skin’s youthful glow and volume, going for a CaHA Filler gives a more natural approach by enhancing your best features. This is another popular option for Singaporeans because of how it delivers a very natural-looking effect by restoring volume and elasticity without looking like you had something done. Its CaHA microspheres also stimulate collagen to give you long-term firming and hydrating benefits.

• Who is it best for: Individuals who want to improve skin elasticity and volume without having to worry about downtime. It’s perfect for those who have very busy lifestyles.
• Longevity: It can vary depending on the skin’s response, but a follow-up session is usually recommended between 6 to 12 months.

 

Here’s a simple comparison table to see what skin layer each injectable targets and why:

Treatment Name	Key Ingredients	Targeted Skin Layer	Why It Targets That Layer
PDLLA Filler	Poly-D,L-lactic acid (PDLLA) + Hyaluronic Acid (HA)	Deep dermis to hypodermis	Designed to restore volume and lift sagging areas by stimulating collagen in deeper tissues.
PDLLA Skin Booster	Poly-D,L-lactic acid (PDLLA) + Hyaluronic Acid (HA)	Papillary to mid-dermis	Targets fine lines and skin texture by stimulating fibroblasts and boosting hydration.
PCL Filler	Polycaprolactone (PCL) microspheres	Mid to deep dermis	Provides structure and stimulates long-term collagen for firmness and wrinkle reduction.
CaHA Filler	Calcium Hydroxylapatite (CaHA) microspheres	Deep dermis to subdermal layer	Offers volumizing and collagen stimulation to treat deep wrinkles and laxity.

 

The Crucial Role of Collagen in Achieving Healthy Skin

Collagen is the most abundant protein in our body, which plays the vital role of holding everything together — think of it as some kind of structural “glue”. We lose collagen as we age, and without enough collagen, the network of fibers in the skin would go weak, and that is what results in sagging skin. This explains why our skin naturally loses its volume as we age. Plus, collagen depletion becomes even more apparent due to many other factors like stress from our fast-paced lifestyles or even the relentless heat we have here in Singapore. 

We lose collagen in different layers of our skin, so it’s important to determine which layer needs more attention. By taking a look at the comparative tables above, you can easily tell each treatment apart to help you determine which is the best collagen stimulator for you. Of course, a thorough consultation with a doctor will allow you to decide on a treatment that’s tailored specifically for you. If you feel like you can amp up your skincare to new heights, collagen stimulators would be a total game-changer in your journey to achieving youthful skin.

 

The Key Takeaway: Invest In Your Skin’s Future

Skincare is never a one-size-fits-all kind of thing. Considering our climate and weather conditions in Singapore, the intense heat causes humidity and harsher UV exposure, which explains why signs of aging can appear faster for us. In addition, life for most of us Singaporeans is pretty fast-paced, and this also contributes to developing different kinds of skin problems that may even worsen over time when not treated right.

This is where collagen stimulators come in to help keep your skin healthy, radiant, and youthful without the hassle and worries of surgical lifts. Collagen stimulators offer a gradual transformation that will last for a long time, making it worth the investment! They work with the natural mechanisms of your body, so you know you won’t get “artificial-looking” results. Apart from being a treatment itself, getting collagen-stimulating procedures can also be a way for you to maintain your youthful skin preventively. This is also one of the many reasons why Singaporeans, as young as those in their 20s, already consider getting these treatments. Think of it as a preventive measure to slow down skin aging before deeper lines occur.

If you’re still undecided on which collagen stimulator treatment is best for you, our doctors here at Ozhean Zoey will help you find the best one according to your skin’s specific needs. Contact us today to learn more.

Since its introduction, Ultherapy has become the gold standard in non-surgical skin lifting treatments worldwide. First approved by the U.S. FDA in 2009 for brow lifts, and later for lifting under the chin, neck, and improving lines and wrinkles on the décolletage, Ultherapy has transformed the landscape of aesthetic medicine. Its ability to stimulate collagen production deep within the skin without requiring surgery or downtime made it a hit not only among doctors but also among the public, celebrities, and influencers.

In the age of social media, Ultherapy has gained further traction. Aesthetic influencers and celebrities have openly endorsed the treatment. Hollywood actress Salma Hayek recently became the global ambassador for Ultherapy Prime, expressing her personal success with the treatment. In Korea, influencers such as Jina Kim (@dearjinakim) and Risabae, a renowned beauty content creator, have also shared their positive experiences with Ultherapy. These endorsements have made Ultherapy a household name for those seeking effective, non-invasive skin rejuvenation.

But aesthetic technology never stands still. At the end of 2024, Merz Aesthetics launched Ultherapy Prime, a newer, more advanced version of the original Ultherapy device. Since its release, Ultherapy Prime has been taking the world by storm, offering both patients and doctors significant improvements over its predecessor.

 

What Makes Ultherapy Prime Unique?

Ultherapy Prime was designed to address patient and practitioner feedback accumulated over more than a decade of clinical use with the original Ultherapy device. The key enhancements include:

• 35% larger screen for better real-time visualization.
• 20% faster treatment time, reducing the overall session length.
• Sharper, more targeted imaging, allowing clinicians to accurately target the skin’s foundational layers, especially the SMAS (Superficial Musculoaponeurotic System) layer, which is responsible for skin laxity.
• Improved ergonomics for both the practitioner and the patient, making the procedure more comfortable.

These enhancements mean more targeted energy delivery, leading to optimal lifting results, enhanced comfort during treatment, and quicker appointments for busy patients.

 

Ultherapy Research and the Importance of Visualization

Ultherapy is not just popular—it is one of the most clinically studied non-invasive lifting devices on the market.

Key Study 1: Werschler et al., 2016

A prospective, open-label pilot study published in the Journal of Clinical and Aesthetic Dermatology demonstrated that 95-100% of patients reported improvements in skin lifting and tightening up to one year after treatment. The study confirmed that Ultherapy leads to collagen contraction and new collagen production, both essential for skin rejuvenation and lifting​.

 

Key Study 2: Pavicic et al., Consensus Review

An international panel of experts concluded that Ultherapy’s visualization technology dramatically improves treatment outcomes. By allowing clinicians to see exactly where the ultrasound energy is delivered, they can avoid under-treatment or over-treatment, ensuring consistent results and minimizing risks.

 

Key Study 3: Alam et al., 2010

A randomized controlled trial published in the Archives of Dermatology showed that ultrasound imaging contributes to better targeting and consistent results in non-invasive skin tightening procedures, reaffirming the importance of visualization in aesthetic ultrasound technologies.

 

Key Study 4: Brobst et al., 2014

Published in the Facial Plastic Surgery Clinics of North America, this study highlighted the efficacy of microfocused ultrasound with visualization (MFU-V), confirming that patients experience visible lifting and skin tightening, particularly when dual-plane treatments are used.

 

Ultherapy Prime: The New Gold Standard (Launched End 2024)

Ultherapy Prime was launched in late 2024 with substantial technological improvements. According to Merz Aesthetics, the platform delivers:

• Sharper and faster imaging capabilities.
• More accurate and consistent energy delivery.
• Reduced treatment time by up to 20%.
• Less discomfort due to improved energy modulation and faster protocols.

The visualization system has also been upgraded, enhancing the practitioner’s ability to accurately treat the SMAS layer while adjusting for patient-specific anatomy.

While long-term clinical studies are underway, early practitioner reports and case studies suggest that Ultherapy Prime offers not only enhanced results but also more pleasant patient comfort compared to the earlier Ultherapy model.

 

Clinical Experience Across the Ozhean Group

At Ozhean Zoey Medical & Aesthetic Clinic, we have been supporting Ultherapy treatments since the technology’s early days. With the introduction of Ultherapy Prime, our clinical experience has revealed several advantages:

• Significantly reduced discomfort compared to traditional Ultherapy.
• Faster treatment sessions, benefiting both patients and practitioners.
• Higher patient satisfaction, with the majority of patients preferring the new device.

We are also extremely proud to share that our Group Medical Director, Dr. Park Ji-Youn, has achieved a significant milestone. Dr. Park has been appointed to the Global Aesthetic Leaders Club for Ultherapy Prime — one of only six doctors in Korea to receive this prestigious recognition. Her appointment reflects not only her expertise but also Ozhean Group’s commitment to staying at the cutting edge of aesthetic medicine. This honor empowers our team to continue providing the most relevant, effective, and safe treatments for our patients.

As part of the Genuine Aesthetic Medical Group from Gangnam, Korea, Ozhean Zoey is proud to lead innovation in non-surgical skin lifting treatments throughout Singapore and beyond.

 

Cost Comparison: Ultherapy vs Ultherapy Prime

Feature	Ultherapy	Ultherapy Prime
Visualization	Yes	Enhanced, faster, more precise
Treatment Time	Standard	20% faster
Patient Comfort	Moderate	Significantly improved
Clinical Evidence	Strong	Strong, with new studies underway
Cost	Base price	5-10% higher, depending on clinic

While Ultherapy Prime does come at a slightly higher price, the benefits of faster treatments, reduced discomfort, and more accurate results make it a worthwhile investment for many patients.

 

Should You Choose Ultherapy or Ultherapy Prime?

Ultimately, the decision comes down to your personal goals and comfort preferences.

If you are looking for an effective, proven treatment and are comfortable with standard treatment times and moderate discomfort, Ultherapy remains a good choice.

However, if you prefer a swifter, more efficient treatment with elevated comfort and potentially even more effective outcomes due to enhanced accuracy, Ultherapy Prime is likely the more ideal option. Many patients find that the slight increase in treatment price is easily justified by the significant improvements in their experience and results.

 

Consider Combining Treatments for Even Better Results

For patients seeking optimal lifting effects, Ultherapy Prime works exceptionally well in combination with collagen biostimulators or "liquid threads". These injectable treatments further boost collagen production, complementing the lifting effects of Ultherapy Prime.

 

Ready to Experience the Future of Skin Lifting?

At Ozhean Zoey Medical & Aesthetic Clinic, our team of experts — led by the internationally recognized Dr. Park Ji-youn — is committed to offering the most effective and modern aesthetic solutions tailored to your individual needs.

Contact us today to schedule a consultation and take the next step towards a more youthful, lifted appearance.

High-Intensity Focused Ultrasound, commonly known as HIFU, has become one of the most popular non-invasive treatments for skin tightening and rejuvenation in Singapore and globally. Originally developed for medical applications such as cancer treatment and neurosurgery, HIFU was adapted for cosmetic purposes in the early 2000s. Its ability to stimulate collagen production and lift the skin without the need for surgery or extended downtime made it an attractive alternative to traditional facelifts.

In 2009, the U.S. Food and Drug Administration (FDA) approved HIFU for non-invasive brow lifting, and subsequent approvals followed for improving lines and wrinkles on the upper chest (décolletage). Today, HIFU treatments offer a customizable, minimally invasive option for individuals seeking skin rejuvenation and lifting without the risks and recovery associated with surgery. In Singapore, the popularity of HIFU has surged due to its safety profile, effectiveness, affordability, and the cultural value placed on maintaining a youthful, refreshed appearance.

 

Ultherapy Prime vs HIFU: History, Technology, and Cost Differences

 

The History of Ultherapy and the Rise of Ultherapy Prime

Ultherapy, developed by Merz Aesthetics in the United States, is widely recognized as the original HIFU technology designed specifically for aesthetic purposes. It was the first non-invasive device cleared by the FDA to lift skin on the brow, neck, and under the chin and to improve the appearance of lines and wrinkles on the décolletage. In 2025, Ultherapy evolved into Ultherapy Prime. This latest version offers significant advancements over the earlier generation. Ultherapy Prime features sharper, faster imaging capabilities, which allow for more accurate targeting of treatment areas. The treatment process has also been refined to be faster and less painful, providing a more comfortable patient experience while delivering even more effective skin lifting results.

 

HIFU as Understood by Most Consumers

When most consumers in Singapore refer to "HIFU," they are usually talking about ultrasound-based skin lifting devices that were developed in Korea. Several well-known Korean brands include Ultraformer, Ultracel, Liftera, and 10Thera. These devices use HIFU technology similar in principle to Ultherapy but are manufactured by various Korean aesthetic companies and differ in design, technology, and performance.

 

Cost Differences Between Ultherapy Prime and Korean HIFU Devices

A key difference between Ultherapy Prime and its Korean counterparts lies in the cost — not just for consumers but also in terms of consumable costs and the price of the machines themselves. Ultherapy Prime treatments typically involve higher upfront costs because of the upgraded technology, consumable costs, and the level of clinical customization offered. Korean HIFU treatments are generally more affordable, making them accessible to a broader range of patients. However, the question remains: how do they compare in terms of actual results and treatment effectiveness?

 

Ultherapy Prime vs HIFU: Which Is More Effective for Skin Lifting?

 

Clinical Evidence for Ultherapy Prime

To date, there are no direct head-to-head clinical studies comparing Ultherapy Prime and Korean HIFU devices. However, several studies have evaluated the effectiveness of Ultherapy (also called Microfocused Ultrasound with Visualization or MFU-V). According to Werschler et al. (2016), Ultherapy treatments resulted in up to 95% to 100% of patients reporting improvements in skin lifting and tightening, with results lasting up to one year. Patients experienced less sagging, fewer lines and wrinkles, and smoother skin texture. Physician assessments confirmed consistent improvements across treated areas, including the brow, jawline, and neck​.

A separate expert consensus review by Pavicic et al. also concluded that Ultherapy's integration of real-time visualization technology allows for targeted energy delivery at the correct skin depths, particularly the SMAS (Superficial Musculoaponeurotic System) layer. This accuracy minimizes the risk of under-treatment or over-treatment, leading to more consistent and effective skin lifting results compared to devices that lack visualization capability.

 

Clinical Evidence for Korean HIFU Devices

While multiple studies have shown that Korean HIFU devices can also improve skin laxity and stimulate collagen production, the results often vary depending on the device used, the treatment protocol, and the practitioner's expertise. Newer Korean devices like 10Thera and Liftera have incorporated modern features, including dual-line delivery and enhanced energy delivery, which reduce treatment time and may improve effectiveness. However, long-term comparative data against Ultherapy Prime is still lacking. To date, no published studies provide a direct clinical comparison between Ultherapy and Korean HIFUs.

 

Why Ultherapy Prime May Offer Superior Targeting

According to Merz, the manufacturer of Ultherapy, the key advantage of Ultherapy Prime lies in its targeted ultrasound shot delivery and consistent treatment depth. The real-time imaging feature allows the practitioner to see exactly where the energy is being delivered, ensuring that the thermal coagulation points are placed accurately at the SMAS layer — the same layer addressed during a surgical facelift. This degree of accuracy is difficult to achieve with most Korean HIFU devices, especially those that lack visualization technology.

Because the energy is consistently delivered to the correct layer, Ultherapy Prime treatments typically produce more effective skin lifting, enhanced jawline definition, and longer-lasting results compared to many other HIFU treatments.

 

The Evolution of Korean HIFU: A Growing Competitor

It is important to acknowledge that newer Korean HIFU models have made significant technological advancements. Devices like 10Thera and Liftera now offer stronger energy delivery and enhanced targeting compared to earlier models. Some models also use double-line technology, which allows for more efficient treatment by delivering energy to two lines simultaneously, effectively reducing treatment time. While these advancements have narrowed the gap between Ultherapy Prime and Korean HIFU devices, differences in visualization technology and clinical evidence remain significant.

 

Ultherapy Prime vs Newer Korean HIFU Devices: Comparison Table

Feature	Ultherapy Prime	Liftera / Ultraformer / Ultracel / 10Thera
Manufacturer	Merz Aesthetics (USA)	Various Korean manufacturers
Imaging Technology	Real-time ultrasound imaging (visualization)	Most models lack imaging; newer models improving
Energy Precision	Highly accurate with consistent depth targeting	Variable; improvement in newer models
Shot Delivery	Single-line, highly controlled	Dual-line in some models (e.g., 10Thera, Liftera)
FDA Clearance	Yes (brow, chin, neck, décolletage)	Varies by device; some models FDA or CE cleared
Customization	Highly customizable with visualization guidance	Limited to device settings; depends on model and operator
Pain / Patient Comfort	Reduced discomfort with Prime version	Newer models have reduced discomfort compared to older HIFUs
Treatment Time	Faster than previous Ultherapy versions	Faster with dual-line models (10Thera, Liftera)
Clinical Evidence	Strong long-term evidence for lifting and tightening	Limited direct comparative studies available
Cost (Consumer)	Higher	Lower

 

Which Skin Lifting Treatment Should You Choose?

If your primary goal is to achieve maximum lifting, accuracy, and long-lasting collagen stimulation, Ultherapy Prime remains the gold standard. Its real-time imaging and strong clinical evidence set it apart from other non-invasive skin lifting treatments. However, if you are seeking a more affordable option or prefer shorter treatment times, newer Korean HIFU devices like Liftera or 10Thera may provide satisfying results, especially for mild to moderate skin laxity.

Ultimately, the ideal choice depends on your skin condition, goals, budget, and treatment expectations. A consultation with an experienced aesthetic doctor can help you determine the most suitable treatment plan.

 

Conclusion

Ultherapy Prime and Korean HIFU devices both offer effective, non-invasive solutions for skin lifting and tightening. Ultherapy Prime leads the field in terms of accuracy, safety, and proven results, while Korean HIFU devices offer a cost-effective alternative with evolving technology. At Ozhean Zoey Medical & Aesthetic Clinic, we offer both options and tailor treatments based on each patient's unique needs and desired outcomes. Speak to us today to learn more.