High-Intensity Focused Ultrasound, commonly known as HIFU, has become one of the most popular non-invasive treatments for skin tightening and rejuvenation in Singapore and globally. Originally developed for medical applications such as cancer treatment and neurosurgery, HIFU was adapted for cosmetic purposes in the early 2000s. Its ability to stimulate collagen production and lift the skin without the need for surgery or extended downtime made it an attractive alternative to traditional facelifts.

In 2009, the U.S. Food and Drug Administration (FDA) approved HIFU for non-invasive brow lifting, and subsequent approvals followed for improving lines and wrinkles on the upper chest (décolletage). Today, HIFU treatments offer a customizable, minimally invasive option for individuals seeking skin rejuvenation and lifting without the risks and recovery associated with surgery. In Singapore, the popularity of HIFU has surged due to its safety profile, effectiveness, affordability, and the cultural value placed on maintaining a youthful, refreshed appearance.

 

Ultherapy vs HIFU: History, Technology, and Cost Differences

 

The History of Ultherapy and the Rise of Ultherapy Prime

Ultherapy, developed by Merz Aesthetics in the United States, is widely recognized as the original HIFU technology designed specifically for aesthetic purposes. It was the first non-invasive device cleared by the FDA to lift skin on the brow, neck, and under the chin and to improve the appearance of lines and wrinkles on the décolletage. In 2025, Ultherapy evolved into Ultherapy Prime. This latest version offers significant advancements over the earlier generation. Ultherapy Prime features sharper, faster imaging capabilities, which allow for more accurate targeting of treatment areas. The treatment process has also been refined to be faster and less painful, providing a more comfortable patient experience while delivering even more effective skin lifting results.

 

HIFU as Understood by Most Consumers

When most consumers in Singapore refer to "HIFU," they are usually talking about ultrasound-based skin lifting devices that were developed in Korea. Several well-known Korean brands include Ultraformer, Ultracel, Liftera, and 10Thera. These devices use HIFU technology similar in principle to Ultherapy but are manufactured by various Korean aesthetic companies and differ in design, technology, and performance.

 

Cost Differences Between Ultherapy and Korean HIFU Devices

A key difference between Ultherapy and its Korean counterparts lies in the cost — not just for consumers but also in terms of consumable costs and the price of the machines themselves. Ultherapy treatments typically involve higher upfront costs because of the upgraded technology, consumable costs, and the level of clinical customization offered. Korean HIFU treatments are generally more affordable, making them accessible to a broader range of patients. However, the question remains: how do they compare in terms of actual results and treatment effectiveness?

 

Ultherapy vs HIFU: Which Is More Effective for Skin Lifting?

 

Clinical Evidence for Ultherapy Prime

To date, there are no direct head-to-head clinical studies comparing Ultherapy Prime and Korean HIFU devices. However, several studies have evaluated the effectiveness of Ultherapy (also called Microfocused Ultrasound with Visualization or MFU-V). According to Werschler et al. (2016), Ultherapy treatments resulted in up to 95% to 100% of patients reporting improvements in skin lifting and tightening, with results lasting up to one year. Patients experienced less sagging, fewer lines and wrinkles, and smoother skin texture. Physician assessments confirmed consistent improvements across treated areas, including the brow, jawline, and neck​.

A separate expert consensus review by Pavicic et al. also concluded that Ultherapy's integration of real-time visualization technology allows for targeted energy delivery at the correct skin depths, particularly the SMAS (Superficial Musculoaponeurotic System) layer. This accuracy minimizes the risk of under-treatment or over-treatment, leading to more consistent and effective skin lifting results compared to devices that lack visualization capability.

 

Clinical Evidence for Korean HIFU Devices

While multiple studies have shown that Korean HIFU devices can also improve skin laxity and stimulate collagen production, the results often vary depending on the device used, the treatment protocol, and the practitioner's expertise. Newer Korean devices like 10Thera and Liftera have incorporated modern features, including dual-line delivery and enhanced energy delivery, which reduce treatment time and may improve effectiveness. However, long-term comparative data against Ultherapy Prime is still lacking. To date, no published studies provide a direct clinical comparison between Ultherapy and Korean HIFUs.

 

Why Ultherapy Prime May Offer Superior Targeting

According to Merz, the manufacturer of Ultherapy, the key advantage of Ultherapy Prime lies in its targeted ultrasound shot delivery and consistent treatment depth. The real-time imaging feature allows the practitioner to see exactly where the energy is being delivered, ensuring that the thermal coagulation points are placed accurately at the SMAS layer — the same layer addressed during a surgical facelift. This degree of accuracy is difficult to achieve with most Korean HIFU devices, especially those that lack visualization technology.

Because the energy is consistently delivered to the correct layer, Ultherapy Prime treatments typically produce more effective skin lifting, enhanced jawline definition, and longer-lasting results compared to many other HIFU treatments.

 

The Evolution of Korean HIFU: A Growing Competitor

It is important to acknowledge that newer Korean HIFU models have made significant technological advancements. Devices like 10Thera and Liftera now offer stronger energy delivery and enhanced targeting compared to earlier models. Some models also use double-line technology, which allows for more efficient treatment by delivering energy to two lines simultaneously, effectively reducing treatment time. While these advancements have narrowed the gap between Ultherapy Prime and Korean HIFU devices, differences in visualization technology and clinical evidence remain significant.

 

Ultherapy vs HIFU: Comparison Table

Feature	Ultherapy Prime	Liftera / Ultraformer / Ultracel / 10Thera
Manufacturer	Merz Aesthetics (USA)	Various Korean manufacturers
Imaging Technology	Real-time ultrasound imaging (visualization)	Most models lack imaging; newer models improving
Energy Precision	Highly accurate with consistent depth targeting	Variable; improvement in newer models
Shot Delivery	Single-line, highly controlled	Dual-line in some models (e.g., 10Thera, Liftera)
FDA Clearance	Yes (brow, chin, neck, décolletage)	Varies by device; some models FDA or CE cleared
Customization	Highly customizable with visualization guidance	Limited to device settings; depends on model and operator
Pain / Patient Comfort	Reduced discomfort with Prime version	Newer models have reduced discomfort compared to older HIFUs
Treatment Time	Faster than previous Ultherapy versions	Faster with dual-line models (10Thera, Liftera)
Clinical Evidence	Strong long-term evidence for lifting and tightening	Limited direct comparative studies available
Cost (Consumer)	Higher	Lower

 

Which Skin Lifting Treatment Should You Choose?

If your primary goal is to achieve maximum lifting, accuracy, and long-lasting collagen stimulation, Ultherapy Prime remains the gold standard. Its real-time imaging and strong clinical evidence set it apart from other non-invasive skin lifting treatments. However, if you are seeking a more affordable option or prefer shorter treatment times, newer Korean HIFU devices like Liftera or 10Thera may provide satisfying results, especially for mild to moderate skin laxity.

Ultimately, the ideal choice depends on your skin condition, goals, budget, and treatment expectations. A consultation with an experienced aesthetic doctor can help you determine the most suitable treatment plan.

 

Conclusion

Ultherapy Prime and Korean HIFU devices both offer effective, non-invasive solutions for skin lifting and tightening. Ultherapy Prime leads the field in terms of accuracy, safety, and proven results, while Korean HIFU devices offer a cost-effective alternative with evolving technology. At Ozhean Zoey Medical & Aesthetic Clinic, we offer both options and tailor treatments based on each patient's unique needs and desired outcomes. Speak to us today to learn more.

Injectable skin booster treatments in Singapore have become higher demand in recent years because of the rising need for efficient skincare. Singaporeans embrace a very active and busy lifestyle, so taking care of one’s skin means going for treatments that are efficient and have minimal downtime. 

Proper hydration is vital in terms of keeping the skin healthy and youthful. But what are the skin booster treatments that are making waves in the Singaporean aesthetic scene these days? And which one is suitable for you? Let’s dive deep into the details, and without a doubt, you’ll be equipped with the right information at the end of this article.

What is a Skin Booster?

Skin boosters are minimally invasive treatments in the form of injectables intended to deeply nourish the skin at the dermal layer. They are different from the traditional dermal fillers most of us know. Skin Boosters don't just focus on structural volume but deliver hydrating and regenerative molecules directly into the skin. This process, which happens as soon as the injection is delivered, will stimulate the production of collagen and elastin to strengthen the skin’s extracellular matrix, resulting in an enhanced look. Most people go for Skin Boosters as part of their regular skin maintenance or to jumpstart their anti-aging treatment.

Common Skin Booster Treatments in Singapore

Many licensed medical clinics in Singapore offer Skin Booster treatments as standalone treatments or as part of their aesthetic treatment programs. In this section, we’ll give you an overview of different types of Skin Boosters available in Singapore — what they do, who they are for, and how they perform.

HA Skin Booster

Hyaluronic acid is a substance that naturally occurs in the body, such as in our skin. It's responsible for providing hydration, firmness, and resilience to our skin cells to keep our skin looking youthful and healthy. The HA (Hyaluronic Acid) Skin Booster features a compound formation called Hybrid Cooperative Complex (HCC), which is perceived as a more potent blend of HA. This blend consists of High molecular Weight HA and Low Molecular Weight HA that work together to keep the skin structure healthy. This results in plumper and more radiant skin.

If your issue is more on skin laxity and sagging, an HA skin booster is something you can consider. Just take note that it only acts as a booster and therefore can offer benefits only up to a certain extent. More severe skin conditions would likely require another treatment to be done together with the HA Skin Booster.

PN Skin Booster (Salmon DNA) 

PN, which is a short term for polynucleotides, is the key ingredient of the PN Skin Booster treatment. This injectable incorporates salmon-derived polynucleotides into the skin, which support dermal repair at a cellular level. The PN Skin Booster injectable performs by stimulating fibroblast activity, reducing inflammation, while also improving the texture and elasticity of the skin.

The PN Skin Booster is an ideal choice for those with sensitive, acne-prone, or sun-damaged skin because of its intensive skin repair effect. It’s typically done in a course of three monthly sessions that last up to 12 months.

Trout DNA Skin Booster

Another type of PN Skin Booster is the one that’s derived from the freshwater trout’s DNA. It’s intricately processed to remove immunogenic proteins. Its difference from the Salmon DNA Skin Booster is that the trout-derived version of the PN Skin Booster has a lower molecular weight. Such a molecular structure allows improved diffusion into the skin and is, therefore, more suitable for areas that are thinner and more delicate.

The Trout DNA Skin Booster is usually administered to target delicate areas such as the eye area, neck, chest, and even hands. Basically, they also offer the same firming, repairing, and hydrating effects as the salmon DNA Booster, but the choice depends on several factors, like skin sensitivity and treatment area.

PDLLA Skin Booster

The PDLLA Skin Booster is an injectable that combines Poly D-Lactic Acid (PDLLA) with non-crosslinked Hyaluronic Acid (HA). Having this combined formula work in your skin will address both immediate and long-term skin concerns, such as wrinkles, fine lines, sagging skin, and textured skin. The way this injectable skin booster performs is by gradually lifting the skin through collagen stimulation. 

This treatment also works as an ideal option for prevention, so it’s recommended to be taken even before signs of aging or damage occur. It’s usually done in multiple sessions spaced a couple of weeks apart, depending on the doctor’s assessment and recommendation. The PDLLA Skin Booster has minimal downtime and also gives progressive, natural-looking results.

OZ Baby Collagen

As the name implies, this skin booster treatment is a collagen-based injectable that introduces bioactive types of collagen into the dermal layers of the skin. Collagen production is crucial in terms of keeping the structure of the skin intact and resilient, so delivering a potent collagen blend will improve skin cell activity within the dermal layers.

If you’re looking for a treatment to help you address textural concerns in your skin, you can consider the OZ Baby Collagen. Just like the previous skin boosters we discussed above, the OZ Baby Collagen booster is also usually administered in a series of sessions spaced over several weeks.

HA + Glycerol Skin Booster

This particular skin booster focuses on hydration through the use of Hyaluronic Acid that’s synergised with glycerol. Glycerol is a humectant that helps retain moisture brought by HA in the dermal layers of the skin. This is ideal for those who suffer from a lack of moisture and elasticity, making the skin easily prone to damage. A series of treatments will improve the way the skin replenishes moisture and improve your skin texture.

Downtime is also minimal with the HA+Glycerol Booster, and with a tailored number of sessions recommended for you, its beneficial effects can last between 6 and 9 months.

Choosing the Right Skin Booster For You

With the number of Skin Booster Treatments in Singapore’s aesthetic scene, choosing the one that’s most suitable for you can be quite a struggle. The right choice begins with a complete understanding of the condition of your skin, as well as what your target goal is. To get a clear picture of what Skin Booster Treatment might be ideal for you, here’s a simple comparative table to take a glance at:

Skin Booster Type	Key Components	Main Intended Benefits	Suitable For	Treatment Plan & Benefit Duration
HA Skin Booster	Hybrid Cooperative Complex of high- and low-molecular-weight Hyaluronic Acid	Improves hydration, firmness, and skin texture	Mild skin laxity, early sagging	Multiple sessions as advised; results last several months
PN Skin Booster (Salmon DNA)	Salmon-derived polynucleotides	Supports dermal repair, improves elasticity, and reduces inflammation	Sensitive, acne-prone, or sun-damaged skin	3 monthly sessions; effects up to ~12 months
PN Skin Booster (Trout DNA)	Trout-derived polynucleotides (lower molecular weight)	Improves hydration, firmness, and repair in delicate areas	Thin skin around eyes, neck, chest, hands	Multiple sessions; results last several months
PDLLA Skin Booster	Poly D-Lactic Acid with non-crosslinked Hyaluronic Acid	Gradually lifts skin, stimulates collagen, improves texture	Early prevention or visible signs of aging	Several sessions weeks apart; progressive results for months
OZ Baby Collagen	Bioactive collagen blend	Supports skin structure, improves texture and resilience	Textural skin concerns	Series over several weeks; results last several months
HA + Glycerol Skin Booster	Hyaluronic Acid with glycerol	Deep hydration, improved elasticity, “glassy” skin effect	Dehydrated, less elastic skin	Tailored sessions; effects last ~6–9 months

There are many factors to consider when choosing the right skin booster for you. It is recommended that you consult a qualified aesthetic clinic’s doctor so that they can provide you with the right option according to your skin’s assessment.

Why are Skin Boosters Common in Singapore

Holistic, subtle, and natural aesthetics are what most Singaporeans prefer, rather than dramatic cosmetic changes. This is what Skin Boosters do — they are subtle, with minimal downtime, and they work with the body’s natural processes, leading to natural-looking results. They are also quite adaptable as they can work as standalone treatments or as a companion to other types of treatments to get better results. 

This makes them versatile and easy to incorporate into your skincare routine. In addition, Singapore’s tropical climate, which can be a bit harsh at times, also accelerates dehydration and causes sun damage that leads to early signs of aging.

Treatment Protocols in Singapore

In Singapore, only licensed medical practitioners can administer skin booster treatments after a thorough assessment by a doctor. These skin booster sessions take a few minutes to administer; however, numbing cream is applied about 30 to 40 minutes prior to the injection.

Most of these skin boosters require a series of sessions to get effective results. While a single session can already give visible results, a consistent treatment plan will bring long-lasting results. The number of sessions and intervals can vary from one patient to another, depending on the patient’s skin response. The doctor’s assessment will adjust the skin booster treatment plan accordingly by basing it on your skin’s natural response.

The Essential Insights For A Youthful, Tailored Glow

The Key Takeaways

• Skin boosters deliver hydration and active ingredients directly into the dermis.
• Options include HA, PN (salmon/trout DNA), PDLLA, collagen, and HA + glycerol formulations.
• Each type targets different needs, from moisture retention to collagen stimulation.
• Treatment plans are tailored to skin type, goals, and response.
• Minimal downtime makes them suitable for busy lifestyles in Singapore.

Skin boosters have established themselves as an option for improving the skin’s overall condition and have become common amongst Singaporeans. These treatments are relatively straightforward, working by delivering active ingredients directly into the dermis to assist in the skin’s natural repair and improvement. You can get visible results without worrying about too much downtime.

As there is a variety of formulations available for Skin Boosters — ranging from hyaluronic acid blends, collagen, and polynucleotides — there’s likely a specific solution for different skin types, areas of focus, and concerns. With thorough consultation with a professional aesthetic doctor, you can follow a treatment plan that matches your aesthetic goals and lifestyle. In Singapore, these procedures are conducted only by licensed medical practitioners who follow established protocols for safety and personalisation. With minimal downtime and natural-looking results, skin boosters can be integrated into a broader approach to maintaining healthy, resilient skin over time.

Ultherapy Prime has quickly gained popularity among those seeking non-invasive skin lifting and tightening. As the upgraded version of the original Ultherapy system, Ultherapy Prime offers faster treatments and enhanced comfort, while still delivering gradual, natural-looking results.

If you’re considering this treatment, understanding what happens before, during, and after can help you feel more confident and prepared—both for the experience and the outcome.

 

What Is Ultherapy Prime?

Ultherapy Prime uses focused ultrasound energy to stimulate your body’s natural collagen production at three specific depths in the skin: the superficial layer, the dermis, and the deeper SMAS layer (which is typically targeted in surgical facelifts). This helps lift, tighten, and firm areas like the brow, jawline, neck, and décolletage—without surgery or needles.

Compared to the original Ultherapy, Ultherapy Prime features:

• A streamlined delivery system for faster treatment time (usually 45–60 minutes)

• A redesigned handpiece for enhanced comfort

• Optimised energy delivery for effective collagen stimulation with reduced discomfort

Now, let’s break down the process and care tips before, during, and after your session.

 

Before Your Ultherapy Prime Treatment

Ultherapy Prime requires little to no special preparation, but there are still a few important steps you can take to ensure a smooth experience.

 

1. Book a Consultation First

Every face is unique, and so is every Ultherapy Prime treatment. A personalised consultation with our doctor helps determine the number of lines (or "shots") needed, and which areas to focus on based on your skin laxity, age, and goals. We’ll also evaluate your medical history to ensure the treatment is suitable for you.

 

2. Avoid Anti-Inflammatories (If Possible)

Unless prescribed for a medical condition, try to avoid anti-inflammatory medications (like ibuprofen or aspirin) a few days before treatment. These can potentially reduce the inflammatory response your body uses to produce new collagen after Ultherapy.

 

3. Stay Hydrated

Proper hydration supports your skin’s overall health and healing response. Drink adequate water in the days leading up to your appointment.

 

4. Skip Aggressive Treatments

Avoid strong chemical peels, laser resurfacing, or other intense facial procedures for at least 1–2 weeks before Ultherapy Prime. Your skin should be calm and free from active irritation or sunburn.

 

During the Treatment: What Happens in the Clinic & What It Feels Like

The treatment session typically lasts 45 to 60 minutes, depending on the areas being treated.

 

1. Topical Numbing for Comfort

To ensure a more comfortable experience, a topical numbing cream will be applied beforehand. Some patients also opt for oral medications or other relaxants, depending on their sensitivity.

 

2. Marking & Mapping the Face

Our doctor will assess and mark the treatment areas to guide accurate and consistent energy delivery. Each zone is mapped out based on anatomical landmarks.

 

3. Ultrasound Imaging for Accuracy

Ultherapy is unique because it uses real-time ultrasound imaging, allowing the doctor to see beneath the skin and deliver energy exactly where it’s needed.

 

4. Delivery of Ultrasound Energy

As the handpiece glides across your skin, you may feel brief moments of heat or tingling beneath the surface—this is the ultrasound energy being delivered. While not usually painful, certain areas (such as the jawline or forehead) can feel more sensitive.

With Ultherapy Prime, patient feedback has shown improved tolerability compared to the older system, thanks to updated energy modulation and ergonomic design.

 

After Ultherapy Prime: What to Expect Post-Treatment & How to Maximise Results

There’s minimal to no downtime after Ultherapy Prime, and most patients return to normal activities right away.

 

1. Immediate Effects

• You might experience slight redness or mild swelling, which typically resolves within a few hours.

• Some people feel a gentle tightness or soreness, especially in areas where the ultrasound penetrated deeper.

• Bruising is rare but may occur in sensitive zones or if you’re prone to it.

 

2. Short-Term Skin Sensations

Over the next few days, you may feel tenderness to touch or a slight tingling sensation beneath the skin—this is normal and indicates collagen remodeling is underway. These sensations usually subside within 1 to 2 weeks.

 

3. No Special Downtime Needed

You can resume makeup, exercise, work, and your regular skincare routine the same or next day. However, it’s best to:

• Avoid hot saunas or steam rooms for 24–48 hours

• Skip vigorous facial massage for a few days

• Use gentle, hydrating skincare to support skin recovery

 

4. When Will You See Results?

Ultherapy Prime works by stimulating your body’s natural collagen production, so results appear gradually over 3 to 6 months.

You might notice subtle firming or lifting earlier, but significant visible improvements take time as collagen builds and strengthens the skin’s deeper layers.

Results typically last 12 to 18 months, though this depends on your lifestyle, skincare habits, and natural aging process. Many patients repeat the treatment annually to maintain their lift.

 

Tips to Maximise Your Ultherapy Prime Results

While Ultherapy Prime doesn’t require ongoing maintenance, here’s how you can support and enhance your outcome:

 

✓ Combine With Complementary Treatments

Ultherapy Prime lifts and firms, but it can be paired with other treatments to address surface-level concerns:

• Skin boosters to improve hydration and glow

• Lasers or peels to even out skin tone or texture

• Biostimulators like PDLLA, PCL and CaHA for enhanced lifting and sculpting

 

✓ Protect With Sunscreen

Daily sun protection prevents collagen breakdown and prolongs your results. Use a broad-spectrum SPF of at least 30, even on cloudy days.

 

✓ Maintain a Collagen-Boosting Routine

Eat collagen-rich foods, stay hydrated, avoid smoking, and use skincare with ingredients like peptides, retinol, or growth factors to support long-term skin health.

 

Final Thoughts

Ultherapy Prime offers a safe, non-invasive option for those looking to lift and firm the face and neck with no surgery, needles, or downtime. By understanding what to expect before, during, and after your treatment, you’ll be better equipped to enjoy your results and take care of your skin in the process.

Interested in seeing if Ultherapy Prime is right for you? Schedule a personalised consultation with our doctor today.