$0.00 0 items

No products in the cart.

Dr. Park Ji-Youn: Are you choosing the wrong types of anti ageing treatments?

April 7, 2022
Pretty lady

A recent American survey1 reported that millennials aged 25-35 are more worried about ageing than their mothers and grandmothers, with the average individual starting an anti-ageing regime as early as 26 years old. 

The same sentiment applies for those in Singapore. 

The earlier need to stave off signs of ageing is thought to be attributed to how millennials place utmost importance on looking good – social media and pop culture now demands everyday individuals to look good from all angles. And while this information isn’t groundbreaking per se, it shows us that our approach to ageing, as with body image, has changed drastically from one generation to the next.

Read: Why muscle building treatments don’t work 

But are you tackling ageing correctly, or worse, wasting money? In this article, we’ll address the common mistakes that both young and mature clients make when it comes to anti ageing treatments, and talk about the solutions available in Singapore today.

Botox, fillers, threadlifts: How you’re getting anti ageing wrong

Fact is, almost every aesthetic treatment can be considered an anti-ageing treatment, as the overall goal of such treatments is mostly to look better and younger. And while a naturally lifted face or enhanced jawline —think botox, threadlifts, HIFU— might contribute to a more youthful look, congruent treatments must be done to improve skin from within.

As aged skin is often a result of poor skin quality and loss of collagen due to factors such as age, smoking, and lifestyles, anti ageing treatments often begin with inducing collagen production and maintaining that. One cannot simply threadlift their way to revitalised youth.

Dare I also say by starting on collagen biostimulation treatments early, you can prevent the need for treatments like botox and fillers in future.

What treatments should I choose to reverse ageing?

Many individuals tend to opt for skinboosters or HA fillers first, as one of the most obvious signs of youthful skin is glowy, hydrated complexion. But let’s not forget beyond a pristine facade, volume and elasticity also play a huge role in a youthful visage. 

When someone looks older than they wish to due to volume depletion, I nudge them toward collagen biostimulators instead. This is because HA fillers can add volume to certain parts of the face only to a certain point; adding more might result in overfilling. 

Collagen biostimulators achieve their anti-ageing goals by directly regenerating collagen in your skin and imparting more substance and shape. For example, Ellansé works to quickly replace lost volume, whilst more robust fillers like Sculptra gradually add fullness to gaunt areas of one’s face.

Both are great, but allow me to introduce two new innovative biostimulator treatments, Nucleofill and Gouri.

Nucleofill and Gouri: The future of anti-ageing treatments?

Nucleofill was formulated in Italy, whilst Gouri was created by a Korean company that specialises in biopolymer (natural polymers produced by our cells) technology. Both treatments are aimed at improving collagen production in the skin, and are low risk and suitable for all skin types.


As the newest technology in biostimulation, Nucleofill is a polynucleotide-based injectable gel specifically designed for natural face shaping and remodelling. 

This highly viscoelastic gel improves skin by:

  • Stimulating dermal fibroblasts and the deeper layers of the skin.
  • Acting as a scavenger of unstable molecules that damage skin (free radicals).
  • Promoting the metabolic activity of cells to restore youthfulness.
  • Producing new collagen in the skin for a natural lift and volumisation.

Fun fact: Nucleofill is derived from biocompatible salmon DNA which offers the skin a younger, healthier appearance.


Gouri is a 100% liquid type PCL injectable from Korea.

Gouri is used for long term skin firming, tightening and distinct wrinkle reduction. 

Here’s why Gouri is an excellent anti-ageing solution:

  • Unlike other fillers which offer revitalising effects on localised partspart only, Gouri spreads naturally to regenerate collagen throughout the entire face.
  • Unlike other existing fillers in the market, Gouri is fully liquid, has no microparticles, homogenously solubilises in water, and presents significantly lower risk.
  • As a biodegradable polymer, Gouri naturally degrades due to hydrolysis.
  • Compared to HA fillers, it has a more long-lasting cosmetic performance.

Comparing Nucleofill and Gouri treatments




What it isAn innovative biotechnology that contains polynucleotides which stimulate the skin and ensure long-lasting skin hydration and firming.A solubilised active and biodegradable polymer injectable that enables collegenesis and

rejuvenation without the use of microparticles.

CompositionGel 2.5% polynucleotides, with pH values of 6.8 to 7.5, and viscosity of 48 to 65 Pa*s.Fully liquid. 21% PCL, or only PCL.
How long does it take for results to show?Roughly 10 to 20 minutes following treatment.Clients normally see their first visual results within 1 to 2 weeks following treatment.
Longevity of resultsResults are long-term and last at least 6 months.Results vary from person to person. As PCL is a high molecular material, the body usually takes 6 to 12 months to degrade it.
Risks involvedThere are no serious side effects, making Nucleofill an effective and safe treatment for all skin types1.Excluding extremely rare cases, the PCL-based filler presents disruptively low risk2 compared to other fillers.
Recommended protocolAfter 3 sessions, additional treatments in 15 to 30 day intervals are recommended for continuous, long-lasting, and effective results.After 3 sessions, an additional 1 to 2 treatments administered in intervals of 4 weeks, or 3 to 6 months are recommended for optimal results.

Why should I consider Nucleofill and Gouri?

Due to the natures of Nucleofill and Gouri, the risk of overfilling, or pillow face syndrome is significantly lowered. These two treatments also present little to no risk, and are known to be consistently long-lasting treatments with a gradual anti-aging effect.

As such, individuals who undergo either Nucleofill or Gouri can expect to experience the following breakthroughs with their skin:

  • Increased skin elasticity
  • Intensely hydrated layers of skin
  • Revitalised skin tone and texture
  • Reinvigorated collagen production
  • Skin lifting and youthful volumisation
  • Repair of skin tissue and damaged cells
  • Significant reduction of fine lines and wrinkles

When combined, they address aging issues on different layers of the face and therefore completely rejuvenate the face.

Can I combine Nucleofill and Gouri with other treatments?

While Nucleofill and Gouri can be compatible with other mesotherapy products, we recommend waiting at least a month before and after undergoing other treatments like HA fillers and other cross-linked materials. 

With Gouri, you can apply non-crosslinked skin boosters or Botoxs. However, do not mix any other products with GOURI. Overall, we would also suggest against mixing Gouri with other products.

Furthermore, as patients usually see long-lasting results and are satisfied with what they see, it’s unlikely that they’ll need supplementary treatments, unless they have specific concerns like acne scars or pigmentation.

When it comes to maintaining your youth, don’t wait till it’s too late. Prevent, not cure! 

Let my team help you restore your youth and stop ageing in its tracks.

About Dr. Park Ji-Youn

Dr. Park Ji-Youn is the founder and managing director of the Ozhean group. As a board certified dermatologist, she has published more than 30 scientific papers on dermatology, and is the creator of Ozhean’s SKIN FIT program, which was conceived in 2015, and continues to successfully retain 80% of its original customers.


  1. https://www.newbeauty.com/millennials-reportedly-worry-more-about-aging-than-their-moms-or-grandmothers/
  2. Park, K. Y., Seok, J., Rho, N. K., Kim, B. J., & Kim, M. N. (2016). Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients. Dermatologic therapy, 29(1), 37–40. https://doi.org/10.1111/dth.12299
  3. Lin, S. L., & Christen, M. O. (2020). Polycaprolactone-based dermal filler complications: A retrospective study of 1111 treatments. Journal of cosmetic dermatology, 19(8), 1907–1914. https://doi.org/10.1111/jocd.13518 
Email: enquiries@ozheanzoey.com

Mon, Wed, Thu & Fri - 10:30 am to 7:30 pm

Tue - 10:30 am - 6:30 pm

Sat - 10:30 am - 4:30 pm

Sundays & Public Holidays - Closed

111 Somerset Road #04-10 TripleOne
Somerset Singapore 238164

©  All rights reserved